Evidence map›Paper›PMID 34842714›Full record

ArticleInfectious disease reports2021

Longitudinal Rise in Seroprevalence of SARS-CoV-2 Infections in Children in Western Germany-A Blind Spot in Epidemiology?

Folke Brinkmann, Hans H Diebner, Chantal Matenar, Anne Schlegtendal, Jan Spiecker, Lynn Eitner, Nina Timmesfeld, Christoph Maier, Thomas Lücke

Open access · goldAbstract read
In one paragraph

Article in Infectious disease reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  13. Seroconversion rate and socio-economic and ethnic risk factors for SARS-CoV-2 infection in children in a population-based cohort, Germany, June 2020 to February 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Folke BrinkmannUniversity Children's Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.ORCID 0000-0002-4307-4232
Hans H DiebnerDepartment of Medical Informatics, Biometry and Epidemiology, Ruhr-University Bochum, 44801 Bochum, Germany.ORCID 0000-0002-7138-6372
Chantal MatenarUniversity Children's Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Anne SchlegtendalUniversity Children's Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Jan SpieckerUniversity Children's Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Lynn EitnerUniversity Children's Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Nina TimmesfeldDepartment of Medical Informatics, Biometry and Epidemiology, Ruhr-University Bochum, 44801 Bochum, Germany.
Christoph MaierUniversity Children's Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Thomas LückeUniversity Children's Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
University Hospitals of the Ruhr-University of Bochum · DERuhr University Bochum · DE

Funding

Federal Ministry of Education and Research 01KI20173
6 · The paper itself

Abstract

SARS-CoV-2 infection rates in children and adolescents are often underestimated due to asymptomatic or oligosymptomatic infections. Seroprevalence studies can reveal the magnitude of "silent" infections in this age group and help to assess the risk of infection for children but also their role in spreading the disease. In total, 2045 children and their parents from the Ruhr region were finally included after the exclusion of drop-outs. Seroconversion rates among children of all age groups increased from 0.5% to 8% during the study period and were about three to fourfold higher than the officially registered PCR-based infection rates. Only 41% recalled symptoms of infection; 59% were asymptomatic. In 51% of the infected children, at least one parent also developed SARS-CoV-2 antibodies. Depending on local incidences, the rates of seroconversion rose to different levels during the study period. Although the dynamics of infection within the study cohort mirrors local incidence, the figure of SARS-CoV-2 infections in children and adolescents appears to be high. Reported contact with SARS-CoV-2-infected individuals in the same household carries a high risk of infection.

Indexed as

childrenSARS-CoV-2seroprevalence

Identifiers

PMID34842714
PMCPMC8629019
OpenAlexW3212459532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.