Evidence map›Paper›PMID 34842686›Full record

ArticleGels (Basel, Switzerland)2021

Injectable and Antioxidative HT/QGA Hydrogel for Potential Application in Wound Healing.

Yikun Ren, Dan Zhang, Yuanmeng He, Rong Chang, Shen Guo, Shanshan Ma, Minghao Yao, Fangxia Guan

Erratum issuedAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yikun RenSchool of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China.
Dan ZhangSchool of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China.
Yuanmeng HeSchool of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China.
Rong ChangSchool of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China.
Shen GuoSchool of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China.
Shanshan MaSchool of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China.
Minghao YaoSchool of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China.
Fangxia GuanSchool of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China.

Funding

Discipline Innovation and Wisdom Introduction Plan of Higher Education in Henan Province CXJD2021002Key R&D and Promotion Projects in Henan Province 202102310211National Natural Science Foundation of China U1804198Zhongyuan Thousand Talents Project 204200510013
6 · The paper itself

Abstract

Hydrogels have gained a niche in the market as wound dressings due to their high water content and plasticity. However, traditional hydrogel wound dressings are difficult to fully adapt to irregular-shaped wound areas. Additionally, excessive reactive oxygen species (ROS) accumulated in the damaged area impede the wound healing process. Therefore, hydrogels with injectable and antioxidant properties offer promising qualities for wound healing, but their design and development remain challenges. In this study, HT/QGA (tyramine-grafted hyaluronic acid/gallic acid-grafted quaternized chitosan) hydrogels with injectable and antioxidant properties were prepared and characterized. This hydrogel exhibited excellent injectability, favorable antioxidant activity, and good biocompatibility. Moreover, we evaluated the therapeutic effect of HT/QGA hydrogel in a full-thickness skin injury model. These results suggested that HT/QGA hydrogel may offer a great potential application in wound healing.

Indexed as

antioxidantbiocompatibilityinjectable hydrogelwound healing

Identifiers

PMID34842686
PMCPMC8628698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.