Evidence map›Paper›PMID 34842668›Full record

ArticleDiseases (Basel, Switzerland)2021

Modulated Electro-Hyperthermic (mEHT) Treatment in the Therapy of Inoperable Pancreatic Cancer Patients-A Single-Center Case-Control Study.

Flora Greta Petenyi, Tamas Garay, Dorottya Muhl, Blanka Izso, Adam Karaszi, Erika Borbenyi, Magdolna Herold, Zoltan Herold, Attila Marcell Szasz, Magdolna Dank

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05889390 ([A Prospective, Randomized Trial to Assess the Added Value of Concomitant Modulated Electro-hyperthermia in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy - an Investigator Initiated Study]), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05889390 phase2 / phase3active not recruitingnot on this mapstarted 2023, after this paper: background citation

[A Prospective, Randomized Trial to Assess the Added Value of Concomitant Modulated Electro-hyperthermia in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy - an Investigator Initiated Study]

TypeinterventionalSponsorSemmelweis UniversityRan2023 to 2026Enrolled71ConditionsHER2-negative Breast CancerArmsOncotherm EHY-2030, Paclitaxel, Carboplatin, Cyclophosphamide/Doxorubicin, Breast cancer removal surgery
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Hyperthermia combined with chemotherapyWorld journal of clinical oncology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Flora Greta PetenyiFaculty of Information Technology and Bionics, Pazmany Peter Catholic University, 1083 Budapest, Hungary.
Tamas GarayFaculty of Information Technology and Bionics, Pazmany Peter Catholic University, 1083 Budapest, Hungary.
Dorottya MuhlDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Blanka IzsoFaculty of Information Technology and Bionics, Pazmany Peter Catholic University, 1083 Budapest, Hungary.
Adam KarasziDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Erika BorbenyiDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Magdolna HeroldDepartment of Internal Medicine and Hematology, Semmelweis University, 1088 Budapest, Hungary.ORCID 0000-0002-1036-6343
Zoltan HeroldDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.ORCID 0000-0001-5990-4889
Attila Marcell SzaszDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Magdolna DankDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Semmelweis University · HUPázmány Péter Catholic University · HU

Funding

National Research, Development and Innovation Office KNN121510National Research, Development and Innovation Office NVKP_16-1-2016-0042
6 · The paper itself

Abstract

Our present oncological treatment arsenal has limited treatment options for pancreatic ductal adenocarcinoma (PDAC). Extended reviews have shown the benefits of hyperthermia for PDAC, supporting the perspectives with the improvements of the treatment possibilities.

methodsA retrospective single-center case-control study was conducted with the inclusion of 78 inoperable PDAC patients. Age-, sex-, chemotherapy-, stage-, and ascites formation-matched patients were assigned to two equal groups based on the application of modulated electro-hyperthermia (mEHT). The EHY2030 mEHT device was used.

resultsA trend in favor of mEHT was found in overall survival (

conclusionmEHT treatment was associated with improved overall survival in PDAC in our single-center retrospective case-control study. The outcome measures encourage us to design a randomized prospective clinical study to further confirm the efficiency of mEHT in this patient cohort.

Indexed as

concomitanthyperthermiamodulated electro-hyperthermiapancreatic neoplasms

Identifiers

PMID34842668
PMCPMC8628793
OpenAlexW3210258682

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.