Evidence map›Paper›PMID 34842646›Full record

ReviewClinics and practice2021

New Aspects of Sarcomas of Uterine Corpus-A Brief Narrative Review.

Stoyan Kostov, Yavor Kornovski, Vesela Ivanova, Deyan Dzhenkov, Dimitar Metodiev, Rafał Watrowski, Yonka Ivanova, Stanislav Slavchev, Dimitar Mitev, Angel Yordanov

Open access · goldAbstract readReview
In one paragraph

Review in Clinics and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Pegylated liposomal doxorubicin combined with trabectedin as a treatment option in uterine sarcomas: a single-institution retrospective analysis.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Clinics and practice · 2022
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Stoyan KostovDepartment of Gynecology, St. Anna University Hospital, Medical University of Varna, 9002 Varna, Bulgaria.ORCID 0000-0002-5279-3095
Yavor KornovskiDepartment of Gynecology, St. Anna University Hospital, Medical University of Varna, 9002 Varna, Bulgaria.
Vesela IvanovaDepartment of General and Clinical Pathology, Faculty of Medicine, Medical University Sofia, 2 Zdrave Str., 1432 Sofia, Bulgaria.ORCID 0000-0001-6335-0831
Deyan DzhenkovDepartment of General and Clinical Pathology, Forensic Medicine and Deontology, Division of General and Clinical Pathology, Faculty of Medicine, Medical University-Varna "Prof. Dr. Paraskev Stoyanov", 9002 Varna, Bulgaria.ORCID 0000-0002-0731-3937
Dimitar MetodievClinical Pathology Laboratory, MHAT "Nadezda" Women's Health Hospital, 1373 Sofia, Bulgaria.
Rafał WatrowskiFaculty Associate, Medical Center-University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0002-6828-1887
Yonka IvanovaDepartment of Gynecology, St. Anna University Hospital, Medical University of Varna, 9002 Varna, Bulgaria.
Stanislav SlavchevDepartment of Gynecology, St. Anna University Hospital, Medical University of Varna, 9002 Varna, Bulgaria.ORCID 0000-0003-4830-6159
Dimitar MitevUniversity Hospital SBALAG "Maichin Dom", Medical University Sofia, 1000 Sofia, Bulgaria.
Angel YordanovDepartment of Gynecologic Oncology, Medical University Pleven, 5800 Pleven, Bulgaria.ORCID 0000-0002-7719-382X
Medical University of Varna · BGMaichin Dom · BGMedical University of Sofia · BGMedical University Pleven · BGUniversity Hospital St. Ivan Rilski · BGUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcomas of the uterine corpus are rare malignant neoplasms, which are further classified into mesenchymal tumors, and mixed (epithelial plus mesenchymal) tumors. The main issues concerning these neoplasms are the small number of clinical trials, insufficient data from evidence-based medicine, insignificant interest from the pharmaceutical industry, all of which close a vicious circle. The low frequency of these malignancies implies insufficient experience in the diagnosis, hence incomplete surgical and complex treatment. Additionally, the rarity of these sarcomas makes it very difficult to develop clinical practice guidelines. Preoperative diagnosis, neoadjuvant and adjuvant chemoradiation, target and hormone therapies still raise many controversies. Disagreements about the role and type of surgical treatment are also often observed in medical literature. There are still insufficient data about the role of pelvic lymph node dissection and fertility-sparing surgery. Pathologists' experience is of paramount importance for an accurate diagnosis. Additionally, genetics examinations become part of diagnosis in some sarcomas of the uterine corpus. Some gene mutations observed in uterine sarcomas are associated with different outcomes. Therefore, a development of molecular classification of uterine sarcomas should be considered in the future. In this review, we focus on the epidemiology, pathogenesis, pathology, diagnosis and treatment of the following sarcomas of the uterine corpus: leiomyosarcoma, low- and high-grade endometrial stromal sarcomas, undifferentiated sarcoma and adenosarcoma. Uterine carcinosarcomas are excluded as they represent an epithelial tumor rather than a true sarcoma.

Indexed as

high-grade endometrial stromal sarcomalow-grade endometrial stromal sarcomaundifferentiated uterine sarcomauterine adenosarcomauterine leiomyosarcoma

Identifiers

PMID34842646
PMCPMC8628735
OpenAlexW3216897017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.