Evidence map›Paper›PMID 34842601›Full record

ArticleInternational journal of neonatal screening2021

Screening of Neonatal UK Dried Blood Spots Using a Duplex SMN1 Screening Assay.

Stuart P Adams, Emma Gravett, Natalie Kent, Susanne Kricke, Adeboye Ifederu, Mariacristina Scoto, Salma Samsuddin, Francesco Muntoni

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of neonatal screening, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05237544 (Newborn Screening for Spinal Muscular Atrophy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05237544 completednot on this map

Newborn Screening for Spinal Muscular Atrophy (SMA) - a Proof of Principle Study Using Anonymised Blood Spots.

TypeobservationalSponsorGreat Ormond Street Hospital for Children NHS Foundation TrustRan2019 to 2021Enrolled5,065ConditionsSpinal Muscular Atrophy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Stuart P AdamsSIHMDS-Haematology, Camelia Botnar Labs, Great Ormond Street Hospital for Children, London WC1N 3JH, UK.ORCID 0000-0002-2650-2848
Emma GravettSIHMDS-Haematology, Camelia Botnar Labs, Great Ormond Street Hospital for Children, London WC1N 3JH, UK.
Natalie KentSIHMDS-Haematology, Camelia Botnar Labs, Great Ormond Street Hospital for Children, London WC1N 3JH, UK.
Susanne KrickeSIHMDS-Haematology, Camelia Botnar Labs, Great Ormond Street Hospital for Children, London WC1N 3JH, UK.ORCID 0000-0003-0791-2291
Adeboye IfederuNewborn Screening Unit, Camelia Botnar Labs, Great Ormond Street Hospital for Children, London WC1N 3JH, UK.
Mariacristina ScotoDevelopmental Neurosciences Research & Teaching Department, Molecular Neurosciences, Dubowitz Neuromuscular Unit, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Salma SamsuddinDevelopmental Neurosciences Research & Teaching Department, Molecular Neurosciences, Dubowitz Neuromuscular Unit, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Francesco MuntoniDevelopmental Neurosciences Research & Teaching Department, Molecular Neurosciences, Dubowitz Neuromuscular Unit, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Great Ormond Street Hospital · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal muscular atrophy (SMA) is an autosomal inherited neuromuscular genetic disease caused, in 95% of cases, by homozygous deletions involving the

Indexed as

dried blood spotNBSnewborn screeningSMASMN1spinal muscular atrophy

Identifiers

PMID34842601
PMCPMC8629004
OpenAlexW3210337531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.