Evidence map›Paper›PMID 34842596›Full record

ReviewActa bio-medica : Atenei Parmensis2021

Update on Food protein-induced enterocolitis syndrome (FPIES).

Mauro Calvani, Caterina Anania, Annamaria Bianchi, Enza D'Auria, Fabio Cardinale, Martina Votto, Alberto Martelli, Mariangela Tosca, Elena Chiappini, Ilaria Brambilla and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Acta bio-medica : Atenei Parmensis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025
    Review
  4. Association of myeloid cell reactivity patterns with safe food predictions in FPIES patients.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025
    Article
  5. Review
  6. World journal of clinical cases · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Whoever goes slowly (after eating) goes far.Acta bio-medica : Atenei Parmensis · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Mauro CalvaniUOC di Pediatria. Azienda Ospedaliera S. Camillo Forlanini, Rome, Italy. maurocalvani58@gmail.com.
Caterina AnaniaDipartimento Materno Infantile e Scienze Urologiche, Policlinico Umberto I, "La Sapienza" University, Rome, Italy. maurocalvani58@gmail.com.
Annamaria BianchiUOC di Pediatria. Azienda Ospedaliera S. Camillo Forlanini, Rome, Italy. annamaria.bianchi9@yahoo.it.
Enza D'AuriaClinica Pediatrica, Ospedale dei Bambini Vittore Buzzi, University of Milan, Milan, Italy. enza.dauria@unimi.it.
Fabio CardinaleDepartment of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy. fabiocardinale@libero.it.
Martina VottoPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. martinavotto@gmail.com.
Alberto MartelliUniversity of Pavia, Pavia, Italy. albmartelli@tiscali.it.
Mariangela ToscaAllergy Centre, IRCCS G. Gaslini Pediatric Hospital, Genova, Italy. mariangelatosca@gaslini.org.
Elena ChiappiniDepartment of Pediatric Infectious Disease, Anna Meyer Children's Hospital, Firenze, Italy. elena.chiappini@unifi.it.
Ilaria BrambillaPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. i.brambilla@smatteo.pv.it.
Michele Miraglia Del GiudiceDepartment of Woman, Child and of General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', Naples, Italy. michele.miragliadelgiudice@unicampania.it.
Carlo CaffarelliPediatric Clinic, Department of Medicine and Surgery, Unversity of Parma, Parma, Italy. carlo.caffarelli@unipr.it.
University of Pavia · ITAzienda Ospedaliera San Camillo-Forlanini · ITIstituto Giannina Gaslini · ITMeyer Children's Hospital · ITOspedale dei Bambini Vittore Buzzi · ITOspedale Pediatrico Giovanni XXIII · ITPoliclinico Umberto I · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated food allergy (FA) characterized by delayed and severe gastrointestinal symptoms that typically occurs within the first year of life. Many aspects of this pathology are currently unclear. FPIES is classified as a non-IgE immune-mediated FA in which the immune response is thought to act mainly through cell-mediated mechanisms. In patients with FPIES, the symptom pattern is determined by the frequency and dose of food allergen in the diet. Diagnosis of FPIES may be difficult, mainly due to the lack of specific biomarkers to confirm or exclude the diagnosis. FPIES is a clinical diagnosis, mainly based on clinical features which, although not specific, are reproducible every time the patient takes the food. Different diagnostic criteria of FPIES were published over time in the literature. The present narrative review aims to analyze the current clinical evidence in epidemiology, pathophysiology, diagnosis, and management of this condition.

Indexed as

EnterocolitisFood HypersensitivityAllergensBiomarkersHumansInfantSyndromeAllergensBiomarkers

Identifiers

PMID34842596
PMCPMC9431892
OpenAlexW3216182824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.