Evidence map›Paper›PMID 34842595›Full record

ReviewActa bio-medica : Atenei Parmensis2021

Use of remdesivir in children with COVID-19 infection: a quick narrative review.

Andrea La Tessa, Marco Antonio Motisi, Gian Luigi Marseglia, Fabio Cardinale, Amelia Licari, Sara Manti, Mariangela Tosca, Michele Miraglia Del Giudice, Maria De Filippo, Luisa Galli and 1 more

Open access · greenAbstract readReview
In one paragraph

Review in Acta bio-medica : Atenei Parmensis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Remdesivir: treatment of COVID-19 in special populations.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Update on COVID-19 Therapy in Pediatric Age.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  9. Article
  10. COVID in Pediatric Age: an opinion paper.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Andrea La TessaDepartment of Pediatric Infectious Disease, Anna Meyer Children's Hospital, Firenze, Italy. elena.chiappini@unifi.it.
Marco Antonio MotisiDepartment of Pediatric Infectious Disease, Anna Meyer Children's Hospital, Firenze, Italy. elena.chiappini@unifi.it.
Gian Luigi MarsegliaPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. elena.chiappini@unifi.it.
Fabio CardinaleDepartment of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy. elena.chiappini@unifi.it.
Amelia LicariPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. elena.chiappini@unifi.it.
Sara MantiDepartment of Clinical and Experimental Medicine, Pediatric Respiratory Unit, San Marco Hospital, University of Catania, Catania, Italy. elena.chiappini@unifi.it.
Mariangela ToscaAllergy Centre, IRCCS G. Gaslini Pediatric Hospital, Genova, Italy. elena.chiappini@unifi.it.
Michele Miraglia Del GiudiceDepartment of Woman, Child and of General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', Naples, Italy. elena.chiappini@unifi.it.
Maria De FilippoPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. elena.chiappini@unifi.it.
Luisa GalliDepartment of Pediatric Infectious Disease, Anna Meyer Children's Hospital, Firenze, Italy. elena.chiappini@unifi.it.
Elena ChiappiniDivision of Paediatric Infectious Disease, Anna Meyer Children's University Hospital, Department of Health Sciences, University of Florence, Florence, Italy.. elena.chiappini@unifi.it.
Meyer Children's Hospital · ITUniversity of Pavia · ITIstituto Giannina Gaslini · ITOspedale Pediatrico Giovanni XXIII · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 infection has a severe course in a small percentage of children. Remdesivir has shown promising results in reducing hospitalisation time in adults, but data on mortality rate are conflicting and few studies are available on its use use in antivirals in children. We performed a quick narrative review of the available literature data regarding the usage of remdesivir in children and neonates. In children, remdesivir showed good safety profile, however bradicardia events have been reported in children. Remdesivir is currently recommended by several guidelines in some subgroups of children with severe COVID-19, and should also be considered in critically ill patients, always in the context of the overall clinical picture and drug availability.

Indexed as

COVID-19 Drug TreatmentAdenosine MonophosphateAdultAlanineChildHumansInfant, NewbornSARS-CoV-2Adenosine MonophosphateAlanineremdesivir

Identifiers

PMID34842595
PMCPMC9431884
OpenAlexW3216634819

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.