Evidence map›Paper›PMID 34842525›Full record

ArticleeLife2021

Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1.

Rania Elsabrouty, Youngah Jo, Seonghwan Hwang, Dong-Jae Jun, Russell A DeBose-Boyd

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Allosteric regulation of UBIAD1 trafficking from ER to Golgi revealed by chemical genetic screening.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Physiological adventures inMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Post-Translational Regulation of HMG CoA Reductase.Cold Spring Harbor perspectives in biology · 2022
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rania ElsabroutyDepartment of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, United States.
Youngah JoDepartment of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, United States.ORCID 0000-0001-6779-3891
Seonghwan HwangDepartment of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, United States.
Dong-Jae JunDepartment of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, United States.
Russell A DeBose-BoydDepartment of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, United States.ORCID 0000-0002-7452-5227
The University of Texas Southwestern Medical Center · US

Funding

TRANSCRIPTIONAL REGULATION OF LDL RECEPTOR PROMOTERP01HL020948 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GOLDSTEIN, JOSEPH L · 1985 to 2021
$103.1M
Significance of UBIAD1 in Regulation of HMG CoA Reductase Degradation, Mevalonate Metabolism, and Menaquinone-4 SynthesisR01GM144039 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI BOOTH, SARAH LOUISE, DEBOSE-BOYD, RUSSELL ALFRED · 2021 to 2024
$1.9M
Examining Mechanism and Physiological Significance of HMG CoA Reductase ER-Associated DegradationR01GM134700 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI DEBOSE-BOYD, RUSSELL ALFRED, LI, XIAOCHUN · 2019 to 2022
$1.7M
NHLBI NIH HHS P01 HL020948NIGMS NIH HHS R01 GM134700NIGMS NIH HHS R01 GM144039
6 · The paper itself

Abstract

UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K

Indexed as

Cell LineDimethylallyltranstransferaseDiterpenesEndoplasmic Reticulum-Associated DegradationGolgi ApparatusHumansHydroxymethylglutaryl CoA ReductasesPhosphoric Monoester HydrolasesPolyisoprenyl PhosphatesDimethylallyltranstransferaseDiterpenesgeranylgeraniolgeranylgeranyl pyrophosphateHydroxymethylglutaryl CoA ReductasesPhosphoric Monoester HydrolasesPolyisoprenyl Phosphatesbiochemistrycell biologychemical biologycholesterol metabolismER-associated degradationhumanisoprenoidsprenylationvesicular transport

Identifiers

PMID34842525
PMCPMC8641950
OpenAlexW3216192050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.