Evidence map›Paper›PMID 34842470›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2022

Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia.

Evans Raballah, Samuel B Anyona, Qiuying Cheng, Elly O Munde, Ivy-Foo Hurwitz, Clinton Onyango, Caroline Ndege, Nicolas W Hengartner, Maria Andreína Pacheco, Ananias A Escalante and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Evans Raballah1104University of New Mexico-Kenya Global Health Programs, Kisumu and Siaya 40100, Kenya.ORCID 0000-0002-3304-6836
Samuel B Anyona1104University of New Mexico-Kenya Global Health Programs, Kisumu and Siaya 40100, Kenya.
Qiuying ChengCenter for Global Health, Department of Internal Medicine, 1104University of New Mexico, Albuquerque, 87131 NM, USA.
Elly O Munde1104University of New Mexico-Kenya Global Health Programs, Kisumu and Siaya 40100, Kenya.
Ivy-Foo HurwitzCenter for Global Health, Department of Internal Medicine, 1104University of New Mexico, Albuquerque, 87131 NM, USA.ORCID 0000-0003-1566-1111
Clinton Onyango1104University of New Mexico-Kenya Global Health Programs, Kisumu and Siaya 40100, Kenya.
Caroline Ndege1104University of New Mexico-Kenya Global Health Programs, Kisumu and Siaya 40100, Kenya.
Nicolas W HengartnerTheoretical Division, Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, 87544 NM, USA.
Maria Andreína PachecoBiology Department/Institute of Genomics and Evolutionary Medicine (iGEM), Temple University, Philadelphia, PA 19122, USA.
Ananias A EscalanteBiology Department/Institute of Genomics and Evolutionary Medicine (iGEM), Temple University, Philadelphia, PA 19122, USA.
Christophe G LambertCenter for Global Health, Department of Internal Medicine, 1104University of New Mexico, Albuquerque, 87131 NM, USA.
Collins Ouma1104University of New Mexico-Kenya Global Health Programs, Kisumu and Siaya 40100, Kenya.
Henri C Jr T ObamaDepartment of Applied Computer and Biosciences, University of Applied Sciences Mittweida, Technikumplatz, Mittweida 09648, Germany.
Kristan A SchneiderDepartment of Applied Computer and Biosciences, University of Applied Sciences Mittweida, Technikumplatz, Mittweida 09648, Germany.
Philip D SeidenbergDepartment of Emergency Medicine, 1104University of New Mexico, Albuquerque, NM 87131, USA.
Benjamin H McMahonTheoretical Division, Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, 87544 NM, USA.
Douglas J Perkins1104University of New Mexico-Kenya Global Health Programs, Kisumu and Siaya 40100, Kenya.ORCID 0000-0001-9390-6255
University of New Mexico · USHochschule Mittweida · DELos Alamos National Laboratory · USTemple University · US

Funding

Partnership for Global Health Research Training Program (Renewal)-Supplement for OBSSR, NCI, NCI-AIDS and NIDCDD43TW010543 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, DAVIDSON HOWES HAMER · 2017 to 2026
$12.1M
Harnessing the Malarial Immunity Omics Landscape in Vaccinated and Unvaccinated Children for Improved Therapeutic StrategiesR01AI130473 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Samuel Bonuke Anyona, Douglas Jay Perkins · 2018 to 2026
$5.6M
TRAINING AND RESEARCH ON SEVERE MALARIAL ANEMIAD43TW005884 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Collins Ouma, Douglas Jay Perkins · 2002 to 2026
$5.2M
GENETIC BASIS OF SEVERE MALARIAL ANEMIAR01AI051305 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PERKINS, DOUGLAS JAY · 2002 to 2011
$4.7M
Dysregulation of the Human Ubiquitin Proteasome System in Pediatric Severe Malarial AnemiaK43TW011581 · FIC · MASENO UNIVERSITY · PI ANYONA, SAMUEL BONUKE · 2020 to 2023
$280k
FIC NIH HHS D43 TW005884FIC NIH HHS D43 TW010543FIC NIH HHS K43 TW011581NIAID NIH HHS R01 AI051305NIAID NIH HHS R01 AI130473
6 · The paper itself

Abstract

Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in holoendemic

Indexed as

AnemiaComplement C3Malaria, FalciparumChildGenetic Predisposition to DiseaseHumansMutationPlasmodium falciparumC3 protein, humanComplement C3C3 missense mutationscomplement systemincident risk ratiomalariaP. falciparumsevere malaria anemia

Identifiers

PMID34842470
PMCPMC9039490
OpenAlexW3215621773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.