ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2021
Investigating the association between physical health comorbidities and disability in individuals with severe mental illness.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Psychosocial and Demographic Factors Associated with Physical Multimorbidity in Severe Mental Illness: A Systematic Review.Schizophrenia bulletin · 2026Pooled it
- A systematic review and meta-analysis of the impact of relaxation techniques to reduce burden of disease in patients with psychotic disorders.Scientific reports · 2026Pooled it
- Relationship between severe mental illness and physical multimorbidity: a meta-analysis and call for action.BMJ mental health · 2023Pooled it
- Insights from Patient and Public Involvement (PPI) in Economic Evaluations of Severe Mental Illness: Comparing Recovering Quality of Life (ReQoL) and the EQ-5D-5L.Applied health economics and health policy · 2026Article
- Temporal relationship between severe mental illness and neurological conditions in a UK primary care cohort.BMJ mental health · 2025Article
- A comparison of the costs and patterns of expenditure for care for severe mental illness in five countries with different levels of economic development.Epidemiology and psychiatric sciences · 2025Article
- (Cost-)effectiveness and implementation of a combined lifestyle intervention for outpatients with severe mental illness (GOAL!): a hybrid quasi-experimental study protocol.BMC psychiatry · 2024Article
- Characteristics of Comorbid Physical Disease in Patients With Severe Mental Illness in South Korea: A Nationwide Population-Based Study (2014-2019).Psychiatry investigation · 2024Article
- Making meaning of multimorbidity and severe mental illness: A viewpoint.The Australian and New Zealand journal of psychiatry · 2024Article
- Use of urgent, emergency and acute care by mental health service users: A record-level cohort study.PloS one · 2023Article
- Impact of the COVID-19 pandemic on non-COVID-19 hospital mortality in patients with schizophrenia: a nationwide population-based cohort study.Molecular psychiatry · 2022Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundResearch suggests that an increased risk of physical comorbidities might have a key role in the association between severe mental illness (SMI) and disability. We examined the association between physical multimorbidity and disability in individuals with SMI.
methodsData were extracted from the clinical record interactive search system at South London and Maudsley Biomedical Research Centre. Our sample (n = 13,933) consisted of individuals who had received a primary or secondary SMI diagnosis between 2007 and 2018 and had available data for Health of Nations Outcome Scale (HoNOS) as disability measure. Physical comorbidities were defined using Chapters II-XIV of the International Classification of Diagnoses (ICD-10).
resultsMore than 60 % of the sample had complex multimorbidity. The most common organ system affected were neurological (34.7%), dermatological (15.4%), and circulatory (14.8%). All specific comorbidities (ICD-10 Chapters) were associated with higher levels of disability, HoNOS total scores. Individuals with musculoskeletal, skin/dermatological, respiratory, endocrine, neurological, hematological, or circulatory disorders were found to be associated with significant difficulties associated with more than five HoNOS domains while others had a lower number of domains affected.
conclusionsIndividuals with SMI and musculoskeletal, skin/dermatological, respiratory, endocrine, neurological, hematological, or circulatory disorders are at higher risk of disability compared to those who do not have those comorbidities. Individuals with SMI and physical comorbidities are at greater risk of reporting difficulties associated with activities of daily living, hallucinations, and cognitive functioning. Therefore, these should be targeted for prevention and intervention programs.
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