Evidence map›Paper›PMID 34841705›Full record

ArticleClinical and translational medicine2021

A cellular census of human peripheral immune cells identifies novel cell states in lung diseases.

Dongli Song, Furong Yan, Huirong Fu, Liyang Li, Jie Hao, Zhenhua Zhu, Ling Ye, Yong Zhang, Meiling Jin, Lihua Dai and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  4. Role of CD4Journal of translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Dongli SongZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.
Furong YanZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.
Huirong FuZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.
Liyang LiZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.ORCID 0000-0003-1107-4155
Jie HaoZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.
Zhenhua ZhuZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.ORCID 0000-0003-1662-7409
Ling YeZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.
Yong ZhangZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.
Meiling JinZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.
Lihua DaiDepartment of Emergency, Shidong Hospital of Yangpu District, Shanghai, China.
Hao FangDepartment of Anesthesiology, Zhongshan Hospital, Shanghai Medical University, Fudan University, Shanghai, China.
Zhenju SongDepartment of Emergency, Zhongshan Hospital, Shanghai Medical University, Fudan University, Shanghai, China.
Duojiao WuZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.ORCID 0000-0003-2562-8825
Xiangdong WangZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Medical University, Fudan University, Shanghai, China.ORCID 0000-0002-1278-3343
Shanghai Medical College of Fudan University · CNYangPu Geriatric Hospital · CN

Funding

Key Subject Construction Program of Shanghai Health Administrative Authority ZK2019B30National Key Research and Development Program 2016YFC0902400National Key Research and Development Program 2017YFC0909500National Key Research and Development Program 2017YFSF090207National Natural Science Foundation of China 81270099National Natural Science Foundation of China 81270131National Natural Science Foundation of China 81300010National Natural Science Foundation of China 81320108001National Natural Science Foundation of China 81700008National Natural Science Foundation of China 81873409National Natural Science Foundation of China 91230204Operation funding of Shanghai Institute of Clinical Bioinformatics, and Ministry of Education for Academic Special Science and Research Foundation for PhD Education 20130071110043Original Research Personalized Support Project of Fudan University IDF152064/011Shanghai Engineering Research Center of Tumour Multi-Target Gene Diagnosis 20DZ2254300The Shanghai Committee of Science and Technology 11410708600The Shanghai Committee of Science and Technology 12431900207The Shanghai Committee of Science and Technology 12JC1402200The Shanghai Committee of Science and Technology 14431905100The Shanghai Committee of Science and Technology 21140902600The Shanghai Committee of Science and Technology 21140902601The Shanghai Committee of Science and Technology 21140902602The Shanghai Committee of Science and Technology 21ZR1412800Zhongshan Distinguished Professor Grant
6 · The paper itself

Abstract

Increasing evidence supports a central role of the immune system in lung diseases. Understanding how immunological alterations between lung diseases provide opportunities for immunotherapy. Exhausted T cells play a key role of immune suppression in lung cancer and chronic obstructive pulmonary disease was proved in our previous study. The present study aims to furthermore define molecular landscapes and heterogeneity of systemic immune cell target proteomic and transcriptomic profiles and interactions between circulating immune cells and lung residential cells in various lung diseases. We firstly measured target proteomic profiles of circulating immune cells from healthy volunteers and patients with stable pneumonia, stable asthma, acute asthma, acute exacerbation of chronic obstructive pulmonary disease, chronic obstructive pulmonary disease and lung cancer, using single-cell analysis by cytometry by time-of-flight with 42 antibodies. The nine immune cells landscape was mapped among those respiratory system diseases, including CD4

Indexed as

CensusesAdultFemaleHumansKiller Cells, NaturalLung DiseasesMaleMiddle Agedacute lung pneumoniaimmunitylung diseasesPD-1

Identifiers

PMID34841705
PMCPMC8611783
OpenAlexW3214826598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.