ArticleMagnetic resonance in medicine2022
The macromolecular MR spectrum does not change with healthy aging.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Age-dependent macromolecule signals in the human motor cortex and thalamus: implications for metabolites quantification at 7 T.Magma (New York, N.Y.) · 2026Article
- Brain metabolite changes in neonates of mothers with SARS-CoV-2 infection during pregnancy: a case-control study.Pediatric radiology · 2026Article
- In vivo brain macromolecules in schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Measures of Brain Metabolism and Diffusion in Neonates of Mothers with Diabetes.AJNR. American journal of neuroradiology · 2026Article
- Reproducibility of Metabolic Mapping Using 2D Multi-Slice Short-TE and GABA-Edited Spin-Echo MRSI at 3T in a Single Protocol.NMR in biomedicine · 2026Article
- The Role of Proton Magnetic Resonance Spectroscopy in Neonatal and Fetal Brain Research.Journal of magnetic resonance imaging : JMRI · 2025Review
- Model-based frequency-and-phase correction ofMagnetic resonance in medicine · 2024Article
- GABA-edited MEGA-PRESS at 3 T: Does a measured macromolecule background improve linear combination modeling?Magnetic resonance in medicine · 2024Article
- Metabolite TNMR in biomedicine · 2024Article
- Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for advanced MRS.Journal of neuroscience methods · 2024Article
- Age-related differences in macromolecular resonances observed in ultra-short-TE STEAM MR spectra at 7T.Magnetic resonance in medicine · 2024Article
- Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for Advanced MRS.bioRxiv : the preprint server for biology · 2024Article
- Impact of acquisition and modeling parameters on the test-retest reproducibility of edited GABA.NMR in biomedicine · 2024Article
- Model-based frequency-and-phase correction ofbioRxiv : the preprint server for biology · 2024Article
- The developmental trajectory of 1H-MRS brain metabolites from childhood to adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- sLASER and PRESS perform similarly at revealing metabolite-age correlations at 3 T.Magnetic resonance in medicine · 2024Article
- Article
- Feasibility and implications of using subject-specific macromolecular spectra to model short echo time magnetic resonance spectroscopy data.NMR in biomedicine · 2023Article
- Impact of gradient scheme and non-linear shimming on out-of-voxel echo artifacts in edited MRS.NMR in biomedicine · 2023Article
- Neurometabolic timecourse of healthy aging.NeuroImage · 2022Article
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14 authors.
Funding
Abstract
purposeTo acquire the mobile macromolecule (MM) spectrum from healthy participants, and to investigate changes in the signals with age and sex.
methods102 volunteers (49 M/53 F) between 20 and 69 years were recruited for in vivo data acquisition in the centrum semiovale (CSO) and posterior cingulate cortex (PCC). Spectral data were acquired at 3T using PRESS localization with a voxel size of 30 × 26 × 26 mm
resultsMM spectra were successfully acquired in 99 (CSO) and 96 (PCC) of 102 subjects. No significant correlations were seen between age and MM signals. One-way ANOVA also suggested no age-group differences for any MM peak (all p > .004). No differences were observed between sex groups. WM and GM voxel fractions showed a significant (p < .05) negative linear association with age in the WM-predominant CSO (R = -0.29) and GM-predominant PCC regions (R = -0.57) respectively while CSF increased significantly with age in both regions.
conclusionOur findings suggest that a pre-defined MM basis function can be used for linear combination modeling of metabolite data from different age and sex groups.
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