Evidence map›Paper›PMID 34841388›Full record

ArticleLancet regional health. Americas2022

Long-term analysis of antibodies elicited by SPUTNIK V: A prospective cohort study in Tucumán, Argentina.

Rossana Elena Chahla, Rodrigo Hernán Tomas-Grau, Silvia Inés Cazorla, Diego Ploper, Esteban Vera Pingitore, Mónica Aguilar López, Patricia Aznar, María Elena Alcorta, Eva María Del Mar Vélez, Agustín Stagnetto and 17 more

Open access · goldAbstract read
In one paragraph

Article in Lancet regional health. Americas, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

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  8. The impact of COVID-19 vaccination programme in the Republic of San Marino: Focus on effectiveness of Gam-Covid-Vac.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Observational
  9. Article
  10. Heterologous prime boost COVID 19 vaccination.Infectious diseases now · 2022
    Article
  11. Article
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  15. Lasting SARS-CoV-2 specific IgG Antibody response in health care workers from Venezuela, 6 months after vaccination with Sputnik V.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 2 countries.

Rossana Elena ChahlaMinisterio de Salud Pública de Tucumán (SIPROSA). Tucumán, Argentina.
Rodrigo Hernán Tomas-GrauInstituto de Investigación en Medicina Molecular y Celular Aplicada IMMCA (UNT-CONICET-SIPROSA). Tucumán, Argentina.
Silvia Inés CazorlaCentro de Referencia para Lactobacilos-CERELA (CONICET). Tucumán, Argentina.
Diego PloperInstituto de Investigación en Medicina Molecular y Celular Aplicada IMMCA (UNT-CONICET-SIPROSA). Tucumán, Argentina.
Esteban Vera PingitoreInstituto de Investigación en Medicina Molecular y Celular Aplicada IMMCA (UNT-CONICET-SIPROSA). Tucumán, Argentina.
Mónica Aguilar LópezLaboratorio de Salud Pública (LSP-SIPROSA). Tucumán, Argentina.
Patricia AznarLaboratorio de Salud Pública (LSP-SIPROSA). Tucumán, Argentina.
María Elena AlcortaLaboratorio de Salud Pública (LSP-SIPROSA). Tucumán, Argentina.
Eva María Del Mar VélezLaboratorio de Salud Pública (LSP-SIPROSA). Tucumán, Argentina.
Agustín StagnettoInstituto de Investigación en Medicina Molecular y Celular Aplicada IMMCA (UNT-CONICET-SIPROSA). Tucumán, Argentina.
César Luís ÁvilaInstituto de Investigación en Medicina Molecular y Celular Aplicada IMMCA (UNT-CONICET-SIPROSA). Tucumán, Argentina.
Carolina Maldonado-GaldeanoCentro de Referencia para Lactobacilos-CERELA (CONICET). Tucumán, Argentina.
Sergio Benjamín SociasInstituto de Investigación en Medicina Molecular y Celular Aplicada IMMCA (UNT-CONICET-SIPROSA). Tucumán, Argentina.
Dar HeinzeDepartment of Medicine, Section of Gastroenterology, Center for Regenerative Medicine (CReM), Boston University School of Medicine. Boston, MA, United States.
Silvia Adriana NavarroInstituto de Investigación en Medicina Molecular y Celular Aplicada IMMCA (UNT-CONICET-SIPROSA). Tucumán, Argentina.
Conrado Juan LlapurMinisterio de Salud Pública de Tucumán (SIPROSA). Tucumán, Argentina.
Dardo CostaLaboratorio de Salud Pública (LSP-SIPROSA). Tucumán, Argentina.
Isolina FloresLaboratorio de Salud Pública (LSP-SIPROSA). Tucumán, Argentina.
Alexis EdelsteinAdministración Nacional de Laboratorios e Institutos de Salud (ANLIS), Dr. Carlos G. Malbrán. Buenos Aires, Argentina.
Shreyas KowdleDepartment of Microbiology at the Icahn School of Medicine at Mount Sinai. New York, NY, United States.
Claudia PerandonesAdministración Nacional de Laboratorios e Institutos de Salud (ANLIS), Dr. Carlos G. Malbrán. Buenos Aires, Argentina.
Benhur LeeDepartment of Microbiology at the Icahn School of Medicine at Mount Sinai. New York, NY, United States.
Gabriela ApfelbaumFacultad de Medicina, Universidad Nacional de Tucumán (UNT). Tucumán, Argentina.
Raúl MostoslavskyThe Massachusetts General Hospital Cancer Center, Harvard Medical School. Boston, MA, United States.
Gustavo MostoslavskyDepartment of Medicine, Section of Gastroenterology, Center for Regenerative Medicine (CReM), Boston University School of Medicine. Boston, MA, United States.
Gabriela PerdigónCentro de Referencia para Lactobacilos-CERELA (CONICET). Tucumán, Argentina.
Rosana Nieves ChehínInstituto de Investigación en Medicina Molecular y Celular Aplicada IMMCA (UNT-CONICET-SIPROSA). Tucumán, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARAdministración Nacional de Laboratorios e Institutos de Salud · ARBoston University · USIcahn School of Medicine at Mount Sinai · USMinisterio de Salud · ARHarvard University · USNational University of Tucumán · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGam-COVID-Vac (SPUTNIK V) has been granted emergency use authorization in 70 nations and has been administered to millions worldwide. However, there are very few peer-reviewed studies describing its effects. Independent reports regarding safety and effectiveness could accelerate the final approval by the WHO. We aimed to study the long-term humoral immune response in naïve and previously infected volunteers who received SPUTNIK V.

methodsHumoral immune responses, assayed by anti-SARS-CoV-2-spike-RBD IgG ELISA and neutralization assays, were measured in 602 healthcare workers at 0, 14, 28, 60 and 180 days after receiving SPUTNIK V between December 2020 and July 2021 in Tucumán, Argentina.

findingsSeroconversion was detected in 97% of individuals after 28 days post-vaccination (dpv) (

interpretationData presented herein provides essential knowledge regarding the kinetics of antibodies induced by SPUTNIK V up to six months after immunization, and suggests that when considering one-dose vaccination policies for individuals with previous SARS-CoV-2 infection, serological studies to determine basal titers may be important, independent of when diagnosis occurred.

fundingTucumán Public Health System (SIPROSA), Argentinean National Research Council (CONICET), National University of Tucumán (UNT).

Indexed as

COVID-19Gam-COVID-VacHumoral inmune responseLong term immunityRBD spikeSARS-CoV-2SeroconversionSPUTNIK V

Identifiers

PMID34841388
PMCPMC8604626
OpenAlexW3216544576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.