Evidence map›Paper›PMID 34841384›Full record

ArticleJournal of affective disorders reports2021

Childhood trauma, major depressive disorder, suicidality, and the modifying role of social support among adolescents living with HIV in rural Uganda.

Scholastic Ashaba, Christine Cooper-Vince, Samuel Maling, Emily N Satinsky, Charles Baguma, Dickens Akena, Denis Nansera, Francis Bajunirwe, Alexander C Tsai

Abstract read
In one paragraph

Article in Journal of affective disorders reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Scholastic AshabaDepartment of Psychiatry, Mbarara University Science and Technology, Mbarara, Uganda.
Christine Cooper-VinceDépartment de Psychiatrie, Universitié de Genève, Switzerland.
Samuel MalingDepartment of Psychiatry, Mbarara University Science and Technology, Mbarara, Uganda.
Emily N SatinskyDepartment of Psychiatry, Mbarara University Science and Technology, Mbarara, Uganda.
Charles BagumaDepartment of Psychiatry, Mbarara University Science and Technology, Mbarara, Uganda.
Dickens AkenaDepartment of Psychiatry, Makerere College of Health Sciences, Makerere, Uganda.
Denis NanseraDepartment of Psychiatry, Mbarara University Science and Technology, Mbarara, Uganda.
Francis BajunirweDepartment of Psychiatry, Mbarara University Science and Technology, Mbarara, Uganda.
Alexander C TsaiDepartment of Psychiatry, Mbarara University Science and Technology, Mbarara, Uganda.

Funding

Mbarara University Research Training Initiative (MURTI)D43TW010128 · FIC · MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY · PI OBUA, CELESTINO · 2015 to 2019
$3.5M
Social Networks, HIV Stigma, and the HIV Care Cascade in Rural UgandaR01MH113494 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI TSAI, ALEXANDER C · 2017 to 2021
$3.2M
The MGH Global Psychiatric Clinical Research Training ProgramT32MH093310 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FRICCHIONE, GREGORY L, HENDERSON, DAVID C · 2012 to 2016
$1.3M
FIC NIH HHS D43 TW010128NIMH NIH HHS R01 MH113494NIMH NIH HHS T32 MH093310
6 · The paper itself

Abstract

backgroundChildhood trauma is associated with mental health problems among adolescents living with HIV (ALHIV) in sub-Saharan Africa, but little is known about potential moderating factors.

methodsWe enrolled 224 ALHIV aged 13-17 years and collected information on childhood trauma, major depressive disorder, and suicidality. We used modified multivariable Poisson regression to estimate the association between the mental health outcome variables and childhood trauma, and to assess for effect modification by social support.

resultsMajor depressive disorder had a statistically significant association with emotional abuse (adjusted relative risk [ARR] 2.57; 95% CI 1.31-5.04; P=0.006) and physical abuse (ARR 2.16; 95% CI 1.19-3.89; P=0.01). The estimated association between any abuse and major depressive disorder was statistically significant among those with a low level of social support (ARR 4.30; 95% CI 1.64-11.25; P=0.003) but not among those with a high level of social support (ARR 1.30; 95% CI 0.57-2.98; P=0.52). Suicidality also had a statistically significant association with emotional abuse (ARR 2.03; 95% CI 1.05-3.920; P=0.03) and physical abuse (ARR 3.17; 95% CI 1.60-6.25.; P=0.001), but no differences by social support were noted. LIMITATIONS: Corporal punishment is used widely in schools and homes as a form of discipline in Uganda; this cultural practice could have biased reporting about physical abuse.

conclusionsChildhood trauma is associated with poor mental health among ALHIV, but its effects may be moderated by social support. More research is needed to develop social support interventions for ALHIV with adverse childhood experiences for improved mental health outcomes.

Indexed as

Adolescentsadverse childhood experiencesHIVmental healthsub-Saharan AfricatraumaUganda

Identifiers

PMID34841384
PMCPMC8623847

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.