Evidence map›Paper›PMID 34841359›Full record

ArticleCurrent research in microbial sciences2021

Characterization of the blood microbiota in children with Celiac disease.

Isha Mehrotra, Gloria Serena, Murat Cetinbas, Victoria Kenyon, Victoria M Martin, Stephanie G Harshman, Ali R Zomorrodi, Ruslan I Sadreyev, Alessio Fasano, Maureen M Leonard

Open access · goldAbstract read
In one paragraph

Article in Current research in microbial sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Pathological Alterations in Human Blood Microbiome-An Updated Review.International journal of molecular sciences · 2025
    Review
  4. Bacteria in the blood of healthy stray dogs infested by ticks in northern Mexico.Journal of advanced veterinary and animal research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Isha MehrotraCenter for Celiac Research and Treatment, MassGeneral Hospital for Children, Yawkey Center for Outpatient Care, Suite 6B, 32 Fruit Street, Boston, MA 02114, USA.
Gloria SerenaCenter for Celiac Research and Treatment, MassGeneral Hospital for Children, Yawkey Center for Outpatient Care, Suite 6B, 32 Fruit Street, Boston, MA 02114, USA.
Murat CetinbasHarvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Victoria KenyonCenter for Celiac Research and Treatment, MassGeneral Hospital for Children, Yawkey Center for Outpatient Care, Suite 6B, 32 Fruit Street, Boston, MA 02114, USA.
Victoria M MartinHarvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Stephanie G HarshmanHarvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Ali R ZomorrodiCenter for Celiac Research and Treatment, MassGeneral Hospital for Children, Yawkey Center for Outpatient Care, Suite 6B, 32 Fruit Street, Boston, MA 02114, USA.
Ruslan I SadreyevHarvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Alessio FasanoCenter for Celiac Research and Treatment, MassGeneral Hospital for Children, Yawkey Center for Outpatient Care, Suite 6B, 32 Fruit Street, Boston, MA 02114, USA.
Maureen M LeonardCenter for Celiac Research and Treatment, MassGeneral Hospital for Children, Yawkey Center for Outpatient Care, Suite 6B, 32 Fruit Street, Boston, MA 02114, USA.
Harvard University · USLemuel Shattuck Hospital · USMaineGeneral Medical Center · USMassachusetts General Hospital · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN TORRIANI · 1994 to 2026
$31.6M
Microbiome-derived Metabolites Linked to Celiac Disease Onset in Infants at RiskR01DK104344 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FASANO, ALESSIO · 2016 to 2020
$3.4M
MGHfC Digestive Disease Summer Research ProgramR25DK103579 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BRYAN P HURLEY · 2015 to 2026
$1.2M
Prospective Multi-Omic Analysis of At-Risk infants to Model Celiac Disease PathogenesisK23DK122127 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LEONARD, MAUREEN MICHELLE · 2019 to 2023
$1.2M
Systems approach to elucidate the microbiome's influence on the development of food allergies early in lifeK23AI151556 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN, VICTORIA MACKENZIE · 2021 to 2025
$998k
NIAID NIH HHS K23 AI151556NIDDK NIH HHS K23 DK122127NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK104344NIDDK NIH HHS R25 DK103579
6 · The paper itself

Abstract

Celiac Disease (CD) is an autoimmune disorder triggered by gluten ingestion that can develop in genetically predisposed individuals. Alterations in the gut microbiota have been suggested to contribute to development of autoimmune conditions including CD. Recent work suggests the existence of a blood microbiota. Evidence that alterations in the blood microbiota potentially influence the development of chronic immune based diseases is increasing. However, there is no published literature regarding the blood microbiota in children, including those with CD. This study aimed to characterize the diversity and taxonomic composition of the blood microbiota of children with CD compared to controls. Whole blood samples were collected from children with active CD, CD in remission, and control subjects and 16S rRNA sequencing was utilized to analyze the blood microbiota. We found 16s rRNA present throughout all pediatric blood samples, providing evidence for the presence of a pediatric blood microbiota. We found significant differences in beta diversity and in abundance of certain taxa (Campylobacterales order, Odoribacteraceae and Helicobacteraceae families,

Indexed as

BacteriaCD, Celiac diseaseCoeliacHematicMicrobiomeOTUs, operational taxonomic unitsPediatrictTG-IgA, Tissue TransGlutaminase ImmunoGlobulin A

Identifiers

PMID34841359
PMCPMC8610358
OpenAlexW3198764462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.