ArticleCell reports. Medicine2021
C-MORE: A high-content single-cell morphology recognition methodology for liquid biopsies toward personalized cardiovascular medicine.
Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cardiomyocyte-specific depletion of integrin α3 preserves cardiac function after myocardial infarction.Basic research in cardiology · 2026Article
- Cardiac Troponin I Antibodies Induce Cardiomyocyte Damage and Alter Cell Morphology.International journal of molecular sciences · 2025Article
- Macrophages enhance sodium channel expression in cardiomyocytes.Basic research in cardiology · 2024Article
- Dynamic hydrogel-metal-organic framework system promotes bone regeneration in periodontitis through controlled drug delivery.Journal of nanobiotechnology · 2024Article
- Optical nanomaterial-based detection of biomarkers in liquid biopsy.Journal of hematology & oncology · 2024Review
- Article
- Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside.Basic research in cardiology · 2023Review
- See more with C-MORE: Addressing the need of robust cardiomyocyte morphological assessment.Cell reports. Medicine · 2021Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular morphology has the capacity to serve as a surrogate for cellular state and functionality. However, primary cardiomyocytes, the standard model in cardiovascular research, are highly heterogeneous cells and therefore impose methodological challenges to analysis. Hence, we aimed to devise a robust methodology to deconvolute cardiomyocyte morphology on a single-cell level: C-MORE (cellular morphology recognition) is a workflow from bench to data analysis tailored for heterogeneous primary cells using our R package cmoRe. We demonstrate its utility in proof-of-principle applications such as modulation of canonical hypertrophy pathways and linkage of genotype-phenotype in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In our pilot study, exposure of cardiomyocytes to blood plasma prior to versus after aortic valve replacement allows identification of a disease fingerprint and reflects partial reversibility following therapeutic intervention. C-MORE is a valuable tool for cardiovascular research with possible fields of application in basic research and personalized medicine.
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Registered trials
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