ArticleCell reports. Medicine2021
Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes.
Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
- Random auditory stimulation during sleep disturbs traveling slow waves and declarative memory.iScience · 2026Article
- Auditory-evoked changes in slow oscillations and spindles correlate with memory consolidation in children with epilepsy and controls.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Neural mass modeling reveals that hyperexcitability underpins slow-wave sleep changes in children with epilepsy.Epilepsia · 2025Article
- Study on brain functional networks and wearable device monitoring in children with SeLECTs and high spike-wave index (SWI >50%).Frontiers in neurology · 2025Article
- Thalamic epileptic spikes disrupt sleep spindles in patients with epileptic encephalopathy.Brain : a journal of neurology · 2024Article
- Single closed-loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo-cortical spindle activity in mice.The European journal of neuroscience · 2024Article
- Different Methods to Estimate the Phase of Neural Rhythms Agree But Only During Times of Low Uncertainty.eNeuro · 2023Article
- Different methods to estimate the phase of neural rhythms agree, but only during times of low uncertainty.bioRxiv : the preprint server for biology · 2023Article
- Automated analysis of a large-scale paediatric dataset illustrates the interdependent relationship between epilepsy and sleep.Scientific reports · 2023Article
- Self-limited childhood epilepsies are disorders of the perisylvian communication system, carrying the risk of progress to epileptic encephalopathies-Critical review.Frontiers in neurology · 2023Review
- Protocol for spike-triggered closed-loop auditory stimulation during sleep in patients with epilepsy.STAR protocols · 2022Article
- Just a sound: A non-pharmacological treatment approach in epilepsy.Cell reports. Medicine · 2021Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Benign epilepsy with centrotemporal spikes (BECTS) is a common form of childhood epilepsy linked to diverse cognitive abnormalities. The electroencephalogram of patients shows focal interictal epileptic spikes, particularly during non-rapid eye movement (NonREM) sleep. Spike formation involves thalamocortical networks, which also contribute to the generation of sleep slow oscillations (SOs) and spindles. Motivated by evidence that SO-spindle activity can be controlled through closed-loop auditory stimulation, here, we show in seven patients that auditory stimulation also reduces spike rates in BECTS. Stimulation during NonREM sleep decreases spike rates, with most robust reductions when tones are presented 1.5 to 3.5 s after spikes. Stimulation further reduces the amplitude of spikes closely following tones. Sleep spindles are negatively correlated with spike rates, suggesting that tone-evoked spindle activity mediates the spike suppression. We hypothesize spindle-related refractoriness in thalamocortical circuits as a potential mechanism. Our results open an avenue for the non-pharmacological treatment of BECTS.
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