Evidence map›Paper›PMID 34841277›Full record

ArticleSTAR protocols2021

Backward simulation for inferring hidden biomolecular kinetic profiles.

Junghun Chae, Roktaek Lim, Cheol-Min Ghim, Pan-Jun Kim

Abstract read
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Junghun ChaeDepartment of Physics, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Roktaek LimDepartment of Biology, Hong Kong Baptist University, Kowloon, Hong Kong.
Cheol-Min GhimDepartment of Physics, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Pan-Jun KimDepartment of Biology, Hong Kong Baptist University, Kowloon, Hong Kong.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our backward simulation (BS) is an approach to infer the dynamics of individual components in ordinary differential equation (ODE) models, given the information on relatively downstream components or their sums. Here, we demonstrate the use of BS to infer protein synthesis rates with a given profile of protein concentrations over time in a circadian system. This protocol can also be applied to a wide range of problems with undetermined dynamics at the upstream levels. For complete details on the use and execution of this protocol, please refer to Lim et al. (2021).

Indexed as

Computer SimulationModels, BiologicalCircadian Rhythm Signaling Peptides and ProteinsKineticsSystems BiologyCircadian Rhythm Signaling Peptides and ProteinsBiophysicsComputer sciencesSystems biology

Identifiers

PMID34841277
PMCPMC8605393

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.