Evidence map›Paper›PMID 34841269›Full record

ArticleCurrent research in physiology2021

Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats.

Olugbenga S Michael, Olubayode Bamidele, Pamela Ogheneovo, Temitope A Ariyo, Lawrence D Adedayo, Olufemi I Oluranti, Elizabeth O Soladoye, Charles O Adetunji, Funmileyi O Awobajo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Olugbenga S MichaelCardiometabolic Research Unit, Department of Physiology, Bowen University, Iwo, Nigeria.
Olubayode BamideleDepartment of Physiology, College of Health Science, Bowen University, Iwo, Nigeria.
Pamela OgheneovoDepartment of Physiology, College of Health Science, Bowen University, Iwo, Nigeria.
Temitope A AriyoDepartment of Physiology, College of Health Science, Bowen University, Iwo, Nigeria.
Lawrence D AdedayoDepartment of Physiology, College of Health Science, Bowen University, Iwo, Nigeria.
Olufemi I OlurantiDepartment of Physiology, College of Health Science, Bowen University, Iwo, Nigeria.
Elizabeth O SoladoyeNebraska Institute of Forensics Sciences, Lincoln, NE, USA.
Charles O AdetunjiMicrobiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology Edo University Iyamho, Edo State, Nigeria.
Funmileyi O AwobajoDepartment of Physiology, College of Medicine, University of Lagos, Idiaraba, Lagos, Nigeria.
Bowen University · NGEdo State University Uzairue · NGUniversity of Lagos · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lead acetate associated tissue injury has been linked to altered antioxidant defenses, hyperuricemia and inflammation. We hypothesized that watermelon rind extract, would ameliorate lead acetate-induced hepato-renal injury. Thirty Male Wistar rats received distilled water, lead acetate (Pb; 5 mg/kg) with or without watermelon rind extract (WM; 400 mg/kg; WM + Pb; 15 days of WM pretreatment); Pb + WM (15 days of WM post treatment) and simultaneous treatment (WM-Pb) for 30 days. Lead toxicity led to elevated serum malondialdehyde, creatinine, urea, uric acid, lactate dehydrogenase, liver injury enzymes, as well as decreased body weight. Decreased serum levels of reduced glutathione, nitric oxide, total protein and glutathione peroxidase activity was also observed. However, these alterations were ameliorated by watermelon rind extract in lead acetate-treated rats. Watermelon rind ethanol extract protects against lead acetate-induced hepato-renal injury through improved antioxidant defenses at least in part, via uric acid/nitric oxide-dependent pathway signifying the health benefits of this agricultural waste and a potential for waste recycling while limiting environmental pollution.

Indexed as

ALP, Alkaline PhosphataseALT, Alanine TransferaseAST, Aspartate TransaminaseGPx, Glutathione PeroxidaseGSH, Reduced GlutathioneLDH, Lactate DehydrogenaseLead acetateMDA, MalondialdehydeNitric oxideOxidative stressPb, Lead Acetaterpm, revolutions per minuteUric acidWatermelonWM, Watermelon rind extract

Identifiers

PMID34841269
PMCPMC8607130
OpenAlexW3212792129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.