Evidence map›Paper›PMID 34840989›Full record

ArticleJournal of immunology research2021

Short-Term Relocation Stress-Induced Hematological and Immunological Changes in

Pramod N Nehete, Bharti P Nehete, Akash G Patel, Sriram Chitta, Henrieta Scholtzova, Lawrence E Williams

Abstract read
In one paragraph

Article in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pramod N NeheteDepartment of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA.ORCID https://orcid.org/0000-0002-2815-2677
Bharti P NeheteDepartment of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA.ORCID https://orcid.org/0000-0002-6632-8872
Akash G PatelCenter for Cognitive Neurology and Department of Neurology, New York University Grossman School of Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0001-6282-9082
Sriram ChittaDepartment of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA.ORCID https://orcid.org/0000-0002-2979-9560
Henrieta ScholtzovaCenter for Cognitive Neurology and Department of Neurology, New York University Grossman School of Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0003-0766-9463
Lawrence E WilliamsDepartment of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA.ORCID https://orcid.org/0000-0003-2267-9918

Funding

Squirrel Monkey Breeding and Research Resource: Resource CoreP40OD010938 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WILLIAM D HOPKINS · 2012 to 2026
$14.9M
Innate Immunity Stimulation via CpG ODN in a Non-Human Primate Model of Sporadic Cerebral Amyloid AngiopathyR01NS102845 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SCHOLTZOVA, HENRIETA · 2017 to 2021
$3.1M
NIH HHS P40 OD010938NINDS NIH HHS R01 NS102845
6 · The paper itself

Abstract

Nonhuman primates are frequently transported to a new location or temporarily relocated within their colony. Both transportation and relocation expose animals to new environments, causing them to undergo a stress response (before adapting). In our NHP colony, the mentioned situations are not infrequent for many reasons, including maintenance. The objective of this study was to determine whether abrupt changes consisting of relocation, housing, separation, and grouping could influence hematological and immunological parameters and thereby functional activity. The current study used squirrel monkeys as a model to investigate the stress-inducing effects of relocation within a facility, while animals acclimated to new situations (physical, housing). A detailed blood analysis revealed significant changes in lymphocytes, triglycerides, total protein, creatinine, and ALT. Flow cytometric analysis of peripheral blood showed reduction in CD3

Indexed as

Adaptation, PhysiologicalAnimalsBehavior, AnimalCells, CulturedDisease Models, AnimalEnzyme-Linked Immunospot AssayFlow CytometryHousing InstabilityHumansInterferon-gammaLymphocytesSaimiriStress, PsychologicalTransportationInterferon-gamma

Identifiers

PMID34840989
PMCPMC8616703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.