Evidence map›Paper›PMID 34840979›Full record

ArticleBioMed research international2021

Downregulation of Rap1GAP Expression Activates the TGF-

Zheng Yan, Wang Yangyanqiu, Han Shuwen, Mao Jing, Liao Haihong, Chen Gong, Jin Yin, Zhou Qing, Gao Weili

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zheng YanDepartment of Pathology, Affiliated Huzhou Hospital Zhejiang University, Affiliated Central Hospital Huzhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province, China 313000.
Wang YangyanqiuGraduate of Affiliated Huzhou Hospital Zhejiang University, Affiliated Central Hospital HuZhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province, China 313000.
Han ShuwenDepartment of Oncology, Affiliated Huzhou Hospital Zhejiang University, Affiliated Central Hospital Huzhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province, China.ORCID https://orcid.org/0000-0001-6180-9565
Mao JingGraduate of Affiliated Huzhou Hospital Zhejiang University, Affiliated Central Hospital HuZhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province, China 313000.
Liao HaihongDepartment of Oncology, Affiliated Huzhou Hospital Zhejiang University, Affiliated Central Hospital Huzhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province, China.
Chen GongDepartment of Laboratory Medicine, Huzhou Central Hospital, Affiliated Central Hospital HuZhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province, China 313000.
Jin YinDepartment of Nursing, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province, China 313000.
Zhou QingDepartment of Thyroid Surgery, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province, China 313000.
Gao WeiliUndergraduate School of Clinic Medicine, Huzhou University, No. 1 Bachelor Road, Huzhou, Zhejiang Province, China 313000.ORCID https://orcid.org/0000-0002-4885-4203
Huzhou University · CNHuzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRap1GAP is considered a tumor suppressor gene, but its regulatory mechanism in papillary thyroid cancer (PTC) has not been clearly elucidated. The aim of this study was to explore whether the regulation between Rap1GAP and sodium/iodine transporter (NIS) in tumorigenesis of PTC is mediated by TGF-

methodsWestern blotting (WB) and quantitative reverse-transcription polymerase chain reaction were performed to analyze the relationships between TGF-

resultsThe results suggested that TGF-

conclusionThe downregulation of Rap1GAP expression can activate the TGF-

Indexed as

AnimalsApoptosisCell Line, TumorCell MovementCell ProliferationDown-RegulationFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGTPase-Activating ProteinsHeterograftsHumansMiceMice, Inbred BALB CMice, NudeNeoplasm InvasivenessGTPase-Activating ProteinsRAP1GAP protein, humanRNA, MessengerRNA, Small InterferingSmad3 ProteinSMAD3 protein, humanSodium-Iodide SymportersSymportersTGFB1 protein, humanTransforming Growth Factor beta1

Identifiers

PMID34840979
PMCPMC8616680
OpenAlexW3213716531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.