Evidence map›Paper›PMID 34840885›Full record

ArticleNeurology. Clinical practice2021

Multiple Spinal CSF Leaks in Spontaneous Intracranial Hypotension: Do They Exist?

Wouter I Schievink, M Marcel Maya, Franklin Moser, Ravi Prasad, Vikram Wadhwa, Rachelle Cruz, Miriam Nuño

Open access · greenAbstract read
In one paragraph

Article in Neurology. Clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  13. Nuclear medicine and molecular imaging · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wouter I SchievinkDepartment of Neurosurgery (WIS, RBC) and Department of Imaging (MM, FGM, RSP, VSW), Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Public Health Sciences (MN), University of California, Davis.
M Marcel MayaDepartment of Neurosurgery (WIS, RBC) and Department of Imaging (MM, FGM, RSP, VSW), Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Public Health Sciences (MN), University of California, Davis.
Franklin MoserDepartment of Neurosurgery (WIS, RBC) and Department of Imaging (MM, FGM, RSP, VSW), Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Public Health Sciences (MN), University of California, Davis.ORCID 0000-0001-5267-2667
Ravi PrasadDepartment of Neurosurgery (WIS, RBC) and Department of Imaging (MM, FGM, RSP, VSW), Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Public Health Sciences (MN), University of California, Davis.
Vikram WadhwaDepartment of Neurosurgery (WIS, RBC) and Department of Imaging (MM, FGM, RSP, VSW), Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Public Health Sciences (MN), University of California, Davis.
Rachelle CruzDepartment of Neurosurgery (WIS, RBC) and Department of Imaging (MM, FGM, RSP, VSW), Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Public Health Sciences (MN), University of California, Davis.ORCID 0000-0003-0758-497X
Miriam NuñoDepartment of Neurosurgery (WIS, RBC) and Department of Imaging (MM, FGM, RSP, VSW), Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Public Health Sciences (MN), University of California, Davis.
Cedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the frequency of multiple spinal CSF leaks in a recent group of patients with spontaneous intracranial hypotension (SIH) who were investigated with digital subtraction myelography (DSM).

methodsThis observational study was conducted using data from a prospectively maintained data base of patients who meet the International Classification of Headache Disorders, third edition, criteria for SIH. The patient population consisted of a consecutive group of 745 patients with SIH who underwent DSM between March 2009 and February 2020. Based on the results of DSM, participants were classified according to the type and number of spinal CSF leaks.

resultsAmong 398 patients with SIH and extradural CSF on spinal imaging, multiplicity of CSF leaks was observed in none of 291 patients with type 1a ventral leaks and in 4 (6.2%) of 65 patients with type 1b (postero-) lateral leaks. Among 97 patients with SIH from spinal CSF-venous fistulas (type 3 leaks) who did not have extradural CSF on spinal imaging, 9 patients (9.3%) had multiple fistulas (

conclusionsAmong patients with SIH, multiplicity of CSF leaks was observed radiographically in none of the patients with ventral leaks, in 6% of patients with lateral leaks, and in 9% of patients with CSF-venous fistulas. These results suggest that patients with SIH can be reassured that the occurrence of multiple CSF leaks is negligible to uncommon at most, depending on the type of CSF leak.

Identifiers

PMID34840885
PMCPMC8610520
OpenAlexW3155041360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.