Evidence map›Paper›PMID 34840752›Full record

ReviewAnnals of medicine and surgery (2012)2021

Metabolic syndrome; associations with adverse outcome after colorectal surgery. A systematic review and meta-analysis.

M Reudink, C D Slooter, L Janssen, A G Lieverse, R M H Roumen, G D Slooter

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine and surgery (2012), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M ReudinkDepartment of Surgery, Máxima Medical Center, Veldhoven, the Netherlands.
C D SlooterAmsterdam University Medical Centers, Location VUmc, Amsterdam, the Netherlands.
L JanssenDepartment of Surgery, Máxima Medical Center, Veldhoven, the Netherlands.
A G LieverseDepartment of Internal Medicine, Máxima Medical Center, Veldhoven, the Netherlands.
R M H RoumenDepartment of Surgery, Máxima Medical Center, Veldhoven, the Netherlands.
G D SlooterDepartment of Surgery, Máxima Medical Center, Veldhoven, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreasing evidence shows that patients with Metabolic Syndrome (MetS) are at risk for adverse outcome after abdominal surgery. The aim of this study was to investigate the impact of MetS and preoperative hyperglycemia, as an individual component of MetS, on adverse outcome after colorectal surgery.

methodsA literature review was systematically performed according to the PRISMA guidelines. Inclusion criteria were observational studies that evaluated the relationship between MetS or preoperative hyperglycemia and outcomes after colorectal surgery (i.e. any complication, severe complication defined as Clavien-Dindo grade ≥ III, anastomotic leakage, surgical site infection, mortality and length of stay).

resultsSix studies (246.383 patients) evaluated MetS and eight studies (9.534 patients) reported on hyperglycemia. Incidence rates of MetS varied widely from 7% to 68% across studies. Meta-analysis showed that patients with MetS are more likely to develop severe complications than those without MetS (RR 1.62, 95% CI 1.01-2.59). Moreover, a non-significant trend toward increased risks for any complication (RR 1.35, 95% CI 0.91-2.00), anastomotic leakage (RR 1.67, 95% CI 0.47-5.93) and mortality (RR 1.19, 95% CI 1.00-1.43) was found. Furthermore, preoperative hyperglycemia was associated with an increased risk of surgical site infection (RR 1.35, 95% CI 1.01-1.81).

conclusionMetS seem to have a negative impact on adverse outcome after colorectal surgery. As a result of few studies meeting inclusion criteria and substantial heterogeneity, evidence is not conclusive. Future prospective observational studies should improve the amount and quality in order to verify current results.

Indexed as

AHA/NHLBI, American Heart Association/National heart Lung and Blood Institute Scientific StatementAMSTAR, A MeaSurement Tool to Assess systematic ReviewsBG, Blood glucoseBMI, Body Mass IndexCAL, Colorectal anastomotic leakageCI, Confidence intervalColorectal surgeryCRC, Colorectal cancerERAS, Enhanced Recovery After SurgeryFPG, Fasting Plasma GlucoseHbA1c, Hemglobin A1cHyperglycemiaIDF, International Diabetes FederationLoS, Length of stayMetabolic syndromeMetS, Metabolic SyndromeNCEP ATP III, National Cholesterol Education Program Adult Treatment Panel IIINHLBI, National Heart, Lung, and Blood InstituteNOS, Newcastle-Ottawa ScalePostoperative outcomePreoperative carePRISMA, Preferred Reporting Items for Systematic Reviews and Meta-AnalysesRR, Risk RatioSSI, Surgical site infectionWHO, World Health Organization

Identifiers

PMID34840752
PMCPMC8606877

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.