Evidence map›Paper›PMID 34840744›Full record

ArticleAnnals of medicine and surgery (2012)2021

Atypical CML with TET2 mutation, associated with NRAS and KRAS: A case report and literature review.

Yousef S Abuzneid, Hussam I A Alzeerelhouseini, Nizar Marzouqa, Yasmine Yaghi, Alaa R Al-Ihribat, Bilal Alqam, Akram Krama

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine and surgery (2012), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yousef S AbuzneidAl-Quds University Faculty of Medicine, Jerusalem, Palestine.
Hussam I A AlzeerelhouseiniAl-Quds University Faculty of Medicine, Jerusalem, Palestine.
Nizar MarzouqaAl-Quds University Faculty of Medicine, Jerusalem, Palestine.
Yasmine YaghiAl-Quds University Faculty of Medicine, Jerusalem, Palestine.
Alaa R Al-IhribatPalestine Polytechnic University, Hebron, Palestine.
Bilal AlqamAl-Quds University Faculty of Medicine, Jerusalem, Palestine.
Akram KramaIstishari Arab Hospital, Ramallah, Palestine.
Al-Quds University · PSPalestine Polytechnic University · PSRafik Hariri University Hospital · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtypical chronic myeloid leukemia ( PRESENTATION OF CASE: We present a case of a 55-year-old female complaining of fever, cough, general weakness and night sweats. Examinations showed leukocytosis with a left shift, thrombocytopenia, hypercellular bone marrow with marked granulocytic hyperplasia and a negative BCR-ABL. After ruling out myelodysplastic and other myeloproliferative diseases the patient was finally diagnosed as aCML according to the WHO criteria with mutations in the TET2 gene, the NRAS gene and in the KRAS gene. The patient was started on Hydroxyurea for a duration of 9 months with an excellent initial response leading to normalization of her platelets and WBCs. However, in the last month she stopped responding to therapy and her state of health started declining once again.

conclusionAtypical chronic myeloid leukemia (

Indexed as

AtypicalCase reportCMLCMMLTET2 mutation

Identifiers

PMID34840744
PMCPMC8606696
OpenAlexW3209108026

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.