ReviewThe Journal of clinical and aesthetic dermatology2021
Guideline for the Safe Use of Hyaluronidase in Aesthetic Medicine, Including Modified High-dose Protocol.
Review in The Journal of clinical and aesthetic dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Guide for Managing Vascular Occlusion Caused by Fillers with Exclusive Cutaneous Involvement: A Review of Diagnosis, Classification, and Treatment.Aesthetic plastic surgery · 2026Pooled it
- Conditions to Consider When Choosing Fillers.Journal of cosmetic dermatology · 2025Pooled it
- Conventional High-Dose vs Low-Dose Hyaluronidase for Skin Necrosis after Hyaluronic Acid Fillers: A Systematic Review and Pilot Meta-Analysis.Aesthetic plastic surgery · 2024Pooled it
- Review
- The clinical evidence and strategic use of hyaluronidase in spinal interventions.Anesthesia and pain medicine · 2026Review
- From permeation enhancer to therapeutic enabler: Advances, applications, and translational perspectives in hyaluronidase-based drug delivery.Materials today. Bio · 2026Review
- Reframing Hyaluronidase in Aesthetic Medicine: From "Dissolving Filler" to "Modifying Filler".Aesthetic surgery journal · 2026Article
- Hyaluronic Acid Dermal Filler-Associated Vascular Occlusion-A Review of Prevention and Management Strategies.Journal of cosmetic dermatology · 2026Review
- Transient Glycocalyx Remodeling by Intravenous Hyaluronidase in Atherosclerosis: A Hypothesis-Generating Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Three-Dimensional Magnetic Resonance Imaging-Guided Localization of Hyaluronic Acid Hydrogel for Precision in Hyaluronidase Injection: A Retrospective Case-Control Study.Aesthetic plastic surgery · 2026Article
- A Preliminary Study of Polycaprolactone Filler After Hyaluronidase for Facial Overfilled Syndrome.Clinical, cosmetic and investigational dermatology · 2026Article
- High-Dose Hyaluronidase for Late-Onset Vascular Complications Following Hyaluronic Acid Filler.Aesthetic plastic surgery · 2026Article
- Hypersensitivity Reaction to Hyaluronidase After Peribulbar Anesthesia for Cataract Surgery: Two Case Reports.Drug, healthcare and patient safety · 2026Article
- Hyaluronidase Use in Aesthetic Medicine: Formulations, Safety, and Clinical Practice.Journal of clinical medicine · 2025Review
- Hyalase in Dermatology: Applications Beyond Filler Management.Journal of cosmetic dermatology · 2025Review
- Freehand Oblique Plane Technique for Ultrasound-guided Hyaluronidase Injections: A Modified Facial Interventional Method.Plastic and reconstructive surgery. Global open · 2025Article
- Comparison of the Degradability of Hyaluronic Acid by Ovine and Recombinant Human Hyaluronidase.Aesthetic surgery journal · 2025Article
- Management of Hyaluronic Acid Filler-Induced Refractory Sterile Abscess With Modified Munhoz-Cavallieri Lavage Protocol: A Case Series.Journal of cosmetic dermatology · 2025Article
- Hyaluronidase: structure, mechanism of action, diseases and therapeutic targets.Molecular biomedicine · 2025Review
- Hyaluronic High Definition Fill Technique.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular occlusions can occur with injection of dermal fillers, causing devastating outcomes for the patient. Hyaluronidase is an enzyme that was first used in general medicine in 1949, but has gained widespread use in aesthetic medicine to dissolve hyaluronic acid (HA)-based dermal fillers. Knowledge of this drug and its use for other aesthetic indications is evolving, and there is often anxiety attached to the administration of animal-derived product due to fears of an allergic reaction. This paper provides guidance on the indications for use when dissolving HA filler with hyaluronidase. It discusses formulation differences, adverse events, allergy to wasp and bee stings, and how this increases risk of allergy to hyaluronidase. It also discusses incidence of allergy, which includes a discussion of types of allergic response and how this correlates to skin tests and a discussion on skin testing for allergy.
Indexed as
Identifiers
34840662PMC8570661W3215123249What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.