Evidence map›Paper›PMID 34840654›Full record

ReviewThe Journal of clinical and aesthetic dermatology2021

Review of Post-laser-resurfacing Topical Agents for Improved Healing and Cosmesis.

Kunal Angra, Michael B Lipp, Sahil Sekhon, Douglas C Wu, Mitchel P Goldman

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of clinical and aesthetic dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Efficacy and Safety of COMedicina (Kaunas, Lithuania) · 2026
    Trial
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. A Topical Formulation ContainingThe Journal of clinical and aesthetic dermatology · 2025
    Article
  14. Dermobile: A cost-effective portable device for erythema evaluation.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  15. Efficacy of Lazolex® Gel in the Treatment of Herpes Simplex Mucocutaneous Infections and the Prevention of Recurrences: A Pilot Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kunal AngraDrs. Angra, Lipp, Wu, and Goldman are with Cosmetic Laser Dermatology in San Diego, California.
Michael B LippDrs. Angra, Lipp, Wu, and Goldman are with Cosmetic Laser Dermatology in San Diego, California.
Sahil SekhonDrs. Angra, Lipp, Wu, and Goldman are with Cosmetic Laser Dermatology in San Diego, California.
Douglas C WuDrs. Angra, Lipp, Wu, and Goldman are with Cosmetic Laser Dermatology in San Diego, California.
Mitchel P GoldmanDrs. Angra, Lipp, Wu, and Goldman are with Cosmetic Laser Dermatology in San Diego, California.
Cosmetic Laser Dermatology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLaser resurfacing produces a controlled skin injury, resulting in a wound healing response. This wound healing response allows for collagen remodeling, which improves skin texture and tone. Topical agents are often employed following laser treatments to facilitate recovery. The introduction of newer small-molecule technologies allow for improved recovery and cosmesis.

objectiveWe sought to perform a critical review of the safety and efficacy of newer small-molecule technologies employed following laser resurfacing.

methodsWe performed a PubMed search of the generic name of the following topicals and included literature relevant to laser procedures, with an emphasis on laser resurfacing: thermal spring water, conjugated linolenic acid, vitamin C/vitamin E/ferulic acid serum, tripeptide/hexapeptide technology-containing products, growth factor serum and gel, recombinant human epidermal growth factor ointment and gel, red deer umbilical cord lining mesenchymal stem cell extract cream and serum, silicone-based gel, and microparticulate (1-3, 1-6 beta-glucan) gel.

resultsOur search of the PubMed database yielded 62 results, out of which 17 clinical studies were included in this publication. The majority of aforementioned topicals show promise in terms of improving post-resurfacing recovery or cosmesis.

conclusionClinical data regarding these agents is limited by the number and quality of studies. It is therefore challenging to propose a recommendation supporting any particular topical. We provide our own provider-specific post-laser resurfacing protocols to offer insight regarding new small-molecule technologies.

Indexed as

healingLaser resurfacingsmall-moleculetopical agentswound care

Identifiers

PMID34840654
PMCPMC8570656
OpenAlexW3217163495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.