ArticleInternational journal of endocrinology2021
Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism.
Article in International journal of endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Thyroid Hormone Resistance Indices and Their Correlations With Insulin Resistance in Chinese Euthyroid Subjects.International journal of endocrinology · 2025Article
- Irisin, a promising adipomyokine, shows low levels in relation to periodontal diseases, unlike visfatin and IL-6 (case-control study).Frontiers in oral health · 2025Article
- Impaired sensitivity to thyroid hormones is associated with hyperuricemia in a Chinese euthyroid population.Frontiers in endocrinology · 2023Article
- Elevated serum Meteorin-like levels in patients with hyperthyroidism.BMC endocrine disorders · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIrisin, a novel myokine, has recently been considered to produce a cardioprotective effect. Potential biomarkers for myocardial injuries in patients with severe hypothyroidism have yet to be identified. We aimed to investigate whether serum irisin may serve as a promising biomarker for early detecting the myocardial injuries in patients with severe hypothyroidism.
methodsThis cross-sectional study comprised 25 newly diagnosed drug-naive patients with severe primary hypothyroidism and 17 age- and sex-matched healthy controls. Circulating irisin levels and cardiac magnetic resonance (CMR) were evaluated in each participant. Left ventricular (LV) myocardial injuries were detected by CMR-based T1 mapping technique using a modified look-locker inversion recovery (MOLLI) sequence, which is quantified as native T1 values.
resultsCompared with healthy controls, the severe hypothyroidism group had significantly lower levels of serum irisin, especially those with pericardial effusion (
conclusionsIrisin may be a potential biomarker for predicting myocardial injuries in patients with severe hypothyroidism.
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Registered trials
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