ArticleScience (New York, N.Y.)2021
A tautomeric ligand enables directed C‒H hydroxylation with molecular oxygen.
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 165 citations in OpenAlex.
- Article
- Aerobic C-H bond activation at a Pd center under aqueous conditions.Chemical science · 2026Article
- RNA-binding proteins in aging and age-related diseases: roles, mechanisms, and a large language model analysis.Biogerontology · 2026Review
- Transition Metal-Catalyzed Direct C(spChemical reviews · 2026Review
- From Mono-Accounts of chemical research · 2025Review
- Practical Ligand-Enabled C-H Halogenation of (Hetero)Benzoic and (Hetero)Aryl Acetic Acids.Journal of the American Chemical Society · 2025Article
- Total Synthesis of the Nominal Structure of (+)-Talaromyolide D.Journal of the American Chemical Society · 2025Article
- Synergistic solvent-catalyst paradigm for sustainable aerobic allylic C-H functionalization.National science review · 2025Article
- Predictable C-H Functionalization of ComplexACS central science · 2025Article
- Direct Pd-Catalyzed β-C(spOrganic letters · 2025Article
- Copper-Catalyzed Cyclization and Alkene Transposition Cascade Enables a Modular Synthesis of Complex Spirocyclic Ethers.Journal of the American Chemical Society · 2025Article
- C3 Selective Hydroxylation of Pyridines via Photochemical Valence Isomerization of PyridineJournal of the American Chemical Society · 2024Article
- A para- to meta-isomerization of phenols.Nature chemistry · 2024Article
- Palladium (II)-Catalyzed C-H Activation with Bifunctional Ligands: From Curiosity to Industrialization.Angewandte Chemie (International ed. in English) · 2024Review
- Direct C-H Hydroxylation ofJournal of the American Chemical Society · 2024Article
- Biomimetic Frustrated Lewis Pair Catalysts for Hydrogenation of CO to Methanol at Low Temperatures.ACS organic & inorganic Au · 2024Article
- Synthesis of meta-carbonyl phenols and anilines.Nature communications · 2024Article
- Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing.Acta pharmaceutica Sinica. B · 2024Review
- Ligand-Enabled Double γ-C(spAngewandte Chemie (International ed. in English) · 2023Article
- A tautomerized ligand enabled meta selective C-H borylation of phenol.Nature communications · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. Infrared, x-ray, and computational analysis support a possible role of ligand tautomerization from mono-anionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.