Evidence map›Paper›PMID 34840331›Full record

ArticleThe Journal of antibiotics2022

New dihydronaphthothiophene derivatives by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12.

Kohei Ishida, Teruki Tanaka, Kenichiro Nagai, Yoshimasa Furuichi, Takeshi Terahara, Masashi Ando, Yasuyuki Tsukamasa, Takashi Fukuda

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kohei IshidaDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
Teruki TanakaDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
Kenichiro NagaiMicrobial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Yoshimasa FuruichiGraduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.
Takeshi TeraharaGraduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.
Masashi AndoDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
Yasuyuki TsukamasaDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
Takashi FukudaDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan. fukudata@nara.kindai.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seriniquinone was originally isolated as a melanoma-selective anti-cancer agent from a culture broth of marine bacteria. Pharmacological studies on its selectivity and unique target are ongoing. A new dihydronaphthothiophene (1) was synthesized by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12, and its derivatives (2-4) were chemically synthesized. Compounds 1-4 exhibited selective cytotoxic activity against melanoma and improved solubility.

Indexed as

ActinobacteriaAntibiotics, AntineoplasticCell Line, TumorDrug Screening Assays, AntitumorHumansJurkat CellsMagnetic Resonance SpectroscopyMolecular StructureStreptomycesAntibiotics, Antineoplastic

Identifiers

PMID34840331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.