Evidence map›Paper›PMID 34840227›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Protein-losing Enteropathy Complicated with Primary Intestinal Follicular Lymphoma.

Tomoki Minemura, Shohei Kikuchi, Hiroshi Mihara, Yusuke Kamihara, Akinori Wada, Mayo Fuchino, Sohachi Nanjo, Akira Noguchi, Takashi Minamisaka, Jun Murakami and 2 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. CD5-positive diffuse large B-Cell lymphoma presenting with protein-losing enteropathy.Journal of clinical and experimental hematopathology : JCEH · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Tomoki MinemuraDepartment of Hematology, Toyama University Hospital, Japan.
Shohei KikuchiDepartment of Hematology, Toyama University Hospital, Japan.
Hiroshi MiharaThird Department of Internal Medicine, Toyama University Hospital, Japan.
Yusuke KamiharaDepartment of Hematology, Toyama University Hospital, Japan.
Akinori WadaDepartment of Hematology, Toyama University Hospital, Japan.
Mayo FuchinoThird Department of Internal Medicine, Toyama University Hospital, Japan.
Sohachi NanjoThird Department of Internal Medicine, Toyama University Hospital, Japan.
Akira NoguchiDepartment of Diagnostic Pathology, Toyama University Hospital, Japan.
Takashi MinamisakaDepartment of Diagnostic Pathology, Toyama University Hospital, Japan.
Jun MurakamiDivision of Transfusion Medicine and Cell Therapy, Toyama University Hospital, Japan.
Ichiro YasudaThird Department of Internal Medicine, Toyama University Hospital, Japan.
Tsutomu SatoDepartment of Hematology, Toyama University Hospital, Japan.
Toyama University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein-losing enteropathy (PLE) is a rare syndrome characterized by hypoproteinemia due to gastrointestinal (GI) protein loss. Primary intestinal follicular lymphoma (PIFL), a specific variant of follicular lymphoma with essential only GI involvement, has not been reported as an etiology of PLE. We herein report a case of PLE complicated with PIFL that was successfully treated with rituximab, resulting in rapid improvement of PLE and a complete response of PIFL. Macroscopic findings of ulcerative lesions with diffuse involvement, which were precisely described by capsule and double-balloon enteroscopy at the diagnosis, also improved following the treatment. This case provides a clue suggesting factors that promote PLE in PIFL.

Indexed as

HypoproteinemiaLymphoma, FollicularProtein-Losing EnteropathiesDouble-Balloon EnteroscopyHumansRituximabRituximabprimary intestinal follicular lymphomaprotein-losing enteropathyrituximab

Identifiers

PMID34840227
PMCPMC9334233
OpenAlexW3215339969

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.