Evidence map›Paper›PMID 34839818›Full record

ArticleMolecular cancer2021

Liquid biopsy identifies actionable dynamic predictors of resistance to Trastuzumab Emtansine (T-DM1) in advanced HER2-positive breast cancer.

Matteo Allegretti, Alessandra Fabi, Elena Giordani, Cristiana Ercolani, Paolo Romania, Cecilia Nisticò, Simona Gasparro, Vittoria Barberi, Maria Ciolina, Edoardo Pescarmona and 4 more

Open access · goldAbstract readLetter
In one paragraph

Article in Molecular cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Research on exosomes in cancer multidrug resistance and clinical translation.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  3. Personalized treatment approach for HER2-positive metastatic breast cancer.Medical oncology (Northwood, London, England) · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Antibody-drug conjugates come of age in oncology.Nature reviews. Drug discovery · 2023
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Matteo Allegretti *Oncogenomics and Epigenetics, IRCSS Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144, Rome, Italy.
Alessandra Fabi *Medical Oncology 1, IRCSS Regina Elena National Cancer Institute, Rome, Italy.
Elena GiordaniOncogenomics and Epigenetics, IRCSS Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144, Rome, Italy.
Cristiana ErcolaniPathology, IRCSS Regina Elena National Cancer Institute, Rome, Italy.
Paolo RomaniaOncogenomics and Epigenetics, IRCSS Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144, Rome, Italy.
Cecilia NisticòMedical Oncology 1, IRCSS Regina Elena National Cancer Institute, Rome, Italy.
Simona GasparroMedical Oncology 1, IRCSS Regina Elena National Cancer Institute, Rome, Italy.
Vittoria BarberiSpecialization School in Oncology, Sapienza University of Rome, Rome, Italy.
Maria CiolinaRadiology and Diagnostic Imaging, IRCSS Regina Elena National Cancer Institute, Rome, Italy.
Edoardo PescarmonaPathology, IRCSS Regina Elena National Cancer Institute, Rome, Italy.
Diana GiannarelliBiostatistical Unit, IRCSS Regina Elena National Cancer Institute, Rome, Italy.
Gennaro CilibertoScientific Direction, IRCSS Regina Elena National Cancer Institute, Rome, Italy.
Francesco CognettiClinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Patrizio GiacominiOncogenomics and Epigenetics, IRCSS Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144, Rome, Italy. patrizio.giacomini@ifo.gov.it.ORCID 0000-0001-6109-1709
Sapienza University of Rome · ITAgostino Gemelli University Polyclinic · ITEpigenomics (Germany) · DE

Funding

Associazione Italiana per la Ricerca sul Cancro 19503H2020 Excellent Science () 633937Lazioinnova A0375-2020-36630
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biomarkers, TumorDrug Resistance, NeoplasmErb-b2 Receptor Tyrosine KinasesLiquid BiopsyAdo-Trastuzumab EmtansineAdultAgedAged, 80 and overBreast NeoplasmsDisease ProgressionFemaleGene AmplificationHumansMiddle AgedNeoplasm GradingNeoplasm StagingAdo-Trastuzumab EmtansineBiomarkers, TumorErb-b2 Receptor Tyrosine KinasesCirculating tumor DNAHER2+ breast cancerLiquid biopsyPharmacological resistanceT-DM1

Identifiers

PMID34839818
PMCPMC8628389
OpenAlexW3215519201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.