Evidence map›Paper›PMID 34839583›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2022

Contributions of side effects to contraceptive discontinuation and method switch among Kenyan women: a prospective cohort study.

C W Rothschild, B A Richardson, B L Guthrie, P Kithao, T Omurwa, J Mukabi, L S Callegari, E L Lokken, G John-Stewart, J A Unger and 2 more

Open access · hybridAbstract read
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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  2. A phenotypicHuman reproduction open · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

C W RothschildDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-2419-9881
B A RichardsonDepartments of Biostatistics and Global Health, University of Washington, Seattle, WA, USA.
B L GuthrieDepartments of Global Health and Epidemiology, University of Washington, Seattle, WA, USA.
P KithaoUniversity of Washington-Kenya, Nairobi, Kenya.
T OmurwaPATH-Kenya, Nairobi, Kenya.
J MukabiPATH-Kenya, Nairobi, Kenya.
L S CallegariDepartments of Obstetrics & Gynecology and Health Services, University of Washington, Seattle, WA, USA.
E L LokkenDepartment of Global Health, University of Washington, Seattle, WA, USA.
G John-StewartDepartments of Global Health, Epidemiology, Medicine, and Pediatrics, University of Washington, Seattle, WA, USA.
J A UngerDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
J KinuthiaDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
A L DrakeDepartment of Global Health, University of Washington, Seattle, WA, USA.
University of Washington · USGoCare Health Solutions Limited · KECape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAKenyatta National Hospital · KEUniversity of Nairobi · KE

Funding

Methods and Data CoreR24HD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI MAR, CORINNE M · 2002 to 2016
$9.3M
Scientific/Technical CoreP2CHD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI SARA R. CURRAN · 2017 to 2026
$6.3M
T32 Data Science and Demography Training BSSRT32HD101442 · NICHD · UNIVERSITY OF WASHINGTON · PI Zack W Almquist, SARA R. CURRAN · 2020 to 2026
$2.0M
Optimizing repeat HIV testing during pregnancy and postpartum for PMTCTK01AI116298 · NIAID · UNIVERSITY OF WASHINGTON · PI DRAKE, ALISON L · 2015 to 2019
$632k
Assessing vaginal microbial communities as a risk factor for HIV acquisition in pregnant and postpartum Kenyan womenF32HD100202 · NICHD · UNIVERSITY OF WASHINGTON · PI LOKKEN, ERICA M · 2019 to 2022
$159k
Contraceptive Side Effects, Method Dissatisfaction, and Early Discontinuation F31HD097841 · NICHD · UNIVERSITY OF WASHINGTON · PI ROTHSCHILD, CLAIRE WATT · 2019 to 2020
$83k
Division of Intramural Research, National Institute of Allergy and Infectious Diseases F32HD100202Division of Intramural Research, National Institute of Allergy and Infectious Diseases K01AI11628Eunice Kennedy Shriver National Institute of Child Health and Human Development F31HD097841Eunice Kennedy Shriver National Institute of Child Health and Human Development T32 HD101442-01NIAID NIH HHS K01 AI116298NICHD NIH HHS F31 HD097841NICHD NIH HHS F32 HD100202NICHD NIH HHS P2C HD042828NICHD NIH HHS R24 HD042828NICHD NIH HHS T32 HD101442
6 · The paper itself

Abstract

objectiveTo determine the contribution of specific contraceptive side effects to method switch and modern-method discontinuation among Kenyan women.

designA prospective cohort study.

settingFive counties in Western Kenya.

participantsWomen aged ≥18 years old and emancipated female minors ≥14 years old using modern, reversible contraception were recruited while attending 10 public health facilities.

methodsPatient-reported adverse effect symptoms, method switch and discontinuation were reported through weekly text message-based surveys for 24 weeks. MAIN OUTCOME MEASUREMENTS: Prevalence, hazards ratio (HR).

resultsAmong 825 women, 44% were using implants, 43% injectables, 7% an intrauterine device and 6% oral contraceptive pills at enrolment. Most (61%) women were continuing a method used in the previous month. During the 24-week follow up, incidence of contraceptive switch was 61.3 per 100 person-years (95% confidence interval [CI] 52.4-71.8) and incidence of discontinuation was 38.5 per 100 person-years (95% CI 31.6-47.0). On average, one-quarter (prevalence [Pr] 0.24, 95% CI 0.22-0.26) of participants reported side effects or method problems weekly, with sexual side effects the most prevalent symptom (Pr 0.15, 95% CI 0.13-0.16). Lack of expected bleeding was associated with higher risk of method switch (adjusted hazard ratio [aHR] 2.36, 95% CI 1.22-4.57). Risk of all-modern method discontinuation was higher among women experiencing irregular bleeding (aHR 2.39, 95% CI 1.20-4.77), weight changes (aHR 2.72, 95% CI 1.47-4.68) and sexual side effects (aHR 2.42, 95% CI 1.40-4.20).

conclusionsAddressing irregular bleeding, weight changes and sexual side effects through development of new products that minimise these specific side effects and anticipatory counseling may reduce method-related discontinuation. TWEETABLE ABSTRACT: Bleeding, weight changes, sexual problems associated with discontinuation of #contraception, but many continue despite side effects.

Indexed as

ContraceptionContraception BehaviorAdolescentAdultContraceptives, Oral, CombinedFemaleHumansKenyaProspective StudiesContraceptives, Oral, CombinedContraceptioncontraceptive discontinuationcontraceptive switchingmenstrual bleeding changessexual side effectsside effects

Identifiers

PMID34839583
PMCPMC9035040
OpenAlexW3216498295

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.