Evidence map›Paper›PMID 34839452›Full record

ArticleNeurochemical research2022

Manganese Intoxication Recovery and the Expression Changes of Park2/Parkin in Rats.

Yu-Min Cao, Xi-Min Fan, Jie Xu, Jie Liu, Qi-Yuan Fan

Abstract read
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In one paragraph

Article in Neurochemical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yu-Min CaoSchool of Public Health, Zunyi Medical University, Zunyi, China.
Xi-Min FanSchool of Public Health, Zunyi Medical University, Zunyi, China.
Jie XuSchool of Public Health, Zunyi Medical University, Zunyi, China.
Jie LiuKey Lab for Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, China. jieliu@zmu.edu.cn.ORCID http://orcid.org/0000-0002-4530-1443
Qi-Yuan FanSchool of Public Health, Zunyi Medical University, Zunyi, China. fanqy@zunyiyizhuan.cn.
Zunyi Medical University · CNIE University · ES

Funding

National Natural Science Foundation of China 81860568
6 · The paper itself

Abstract

Occupational overexposure to manganese (Mn) produces Parkinson's disease-like manganism. Acute Mn intoxication in rats causes dopaminergic neuron loss, impairment of motor activity and reduction of the expression of Park2/Parkin. The expression of Park2/Parkin is also reduced. Whether these changes are reversible after cessation of Mn exposure is unknown, and is the goal of this investigation. Adult male rats were injected with Mn

Indexed as

ManganeseManganese PoisoningAnimalsDopaminergic NeuronsMaleRatsTyrosine 3-MonooxygenaseUbiquitin-Protein LigasesManganeseparkin proteinTyrosine 3-MonooxygenaseUbiquitin-Protein LigasesBehavioral activityDopaminergic neuronsManganeseMn accumulationPark2/ParkinRecovery after exposure

Identifiers

PMID34839452
OpenAlexW3217471483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.