Evidence map›Paper›PMID 34839380›Full record

SynthesisNeuroradiology2022

Application of artificial intelligence and radiomics in pituitary neuroendocrine and sellar tumors: a quantitative and qualitative synthesis.

Kelvin Koong, Veronica Preda, Anne Jian, Benoit Liquet-Weiland, Antonio Di Ieva

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Computational Pipeline in Neuroradiomics.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  5. Article
  6. Article
  7. Rathke's cleft cyst: From history to molecular genetics.Reviews in endocrine & metabolic disorders · 2025
    Review
  8. Applications and Integration of Radiomics for Skull Base Oncology.Advances in experimental medicine and biology · 2024
    Review
  9. Review
  10. Machine Learning and Radiomics in Gliomas.Advances in experimental medicine and biology · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kelvin KoongComputational NeuroSurgery (CNS) Lab, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Veronica PredaMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Anne JianComputational NeuroSurgery (CNS) Lab, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Benoit Liquet-WeilandComputational NeuroSurgery (CNS) Lab, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Antonio Di IevaComputational NeuroSurgery (CNS) Lab, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia. antonio.diieva@mq.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo systematically review the literature regarding the application of machine learning (ML) of magnetic resonance imaging (MRI) radiomics in common sellar tumors. To identify future directions for application of ML in sellar tumor MRI.

methodsPubMed, Medline, Embase, Google Scholar, Scopus, ArxIV, and bioRxiv were searched to identify relevant studies published between 2010 and September 2021. Studies were included if they specifically involved ML of MRI radiomics in the analysis of sellar masses. Risk of bias assessment was performed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) Tool.

resultsFifty-eight articles were identified for review. All papers utilized retrospective data, and a quantitative systematic review was performed for thirty-one studies utilizing a public dataset which compared pituitary adenomas, meningiomas, and gliomas. One of the analyzed architectures yielded the highest classification accuracy of 0.996. The remaining twenty-seven articles were qualitatively reviewed and showed promising findings in predicting specific tumor characteristics such as tumor consistency, Ki-67 proliferative index, and post-surgical recurrence.

conclusionThis review highlights the potential clinical application of ML using MRI radiomic data of the sellar region in diagnosis and predicting treatment outcomes. We describe future directions for practical application in the clinical care of patients with pituitary neuroendocrine and other sellar tumors.

Indexed as

Meningeal NeoplasmsPituitary NeoplasmsArtificial IntelligenceHumansMagnetic Resonance ImagingPituitary GlandRetrospective StudiesArtificial intelligenceDeep learningMachine learningMagnetic resonance imagingPituitary neoplasmsRadiomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.