Evidence map›Paper›PMID 34839360›Full record

ArticleTranslational psychiatry2021

Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.

Kelly Smart, Ashley Yttredahl, Maria A Oquendo, J John Mann, Ansel T Hillmer, Richard E Carson, Jeffrey M Miller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Kelly SmartYale PET Center, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4775-6943
Ashley YttredahlMolecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY, USA.
Maria A OquendoDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, PA, CT, USA.
J John MannMolecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY, USA.
Ansel T HillmerYale PET Center, Yale School of Medicine, New Haven, CT, USA.
Richard E CarsonYale PET Center, Yale School of Medicine, New Haven, CT, USA.
Jeffrey M MillerMolecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY, USA. jeffrey.miller@nyspi.columbia.edu.ORCID http://orcid.org/0000-0002-2206-9311
Yale Cancer Center · USNew York State Psychiatric InstituteNew York Psychoanalytic Society and Institute · USUniversity of Pennsylvania · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
The Brief Research in Aging and Interdisciplinary NeurosciencesT35AG044303 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sachin Agarwal, Jennifer Jaie Manly · 2013 to 2026
$1.9M
Multimodal Neuroimaging of Alcohol Withdrawal: The Role of Glutamate in Neural ReorganizationK01AA024788 · NIAAA · YALE UNIVERSITY · PI HILLMER, ANSEL · 2017 to 2021
$894k
Novel Mechanisms Underlying Depression: PET Imaging of the Kappa Opioid ReceptorR21MH091553 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, JEFFREY M · 2011 to 2012
$462k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA024788NIA NIH HHS T35 AG044303NIMH NIH HHS R21 MH091553
6 · The paper itself

Abstract

Preclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positron emission tomography (PET) with the KOR radiotracer [

Indexed as

Major Depressive DisorderReceptors, Opioid, kappaAdultBrainCase-Control StudiesFemaleFrontal LobeGyrus CinguliHumansPositron-Emission TomographyOPRK1 protein, humanReceptors, Opioid, kappa

Identifiers

PMID34839360
PMCPMC8627509
OpenAlexW3214899326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.