ArticleTranslational psychiatry2021
Psychological and biological resilience modulates the effects of stress on epigenetic aging.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis.Clinical epigenetics · 2026Pooled it
- Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Workaholism as a neglected risk factor for unhealthy aging: implications for the Semmelweis-EUniWell Workplace Health Promotion Program.GeroScience · 2026Article
- Accelerated aging in schizophrenia: integrating epigenetic clocks, telomere dynamics, senescence-associated secretory phenotype, and oxidative stress.European archives of psychiatry and clinical neuroscience · 2026Review
- Polygenic Resilience Scores are Associated With Lower Penetrance of Schizophrenia Risk Genes, Protection Against Psychiatric and Medical Disorders, and Enhanced Mental Well-Being and Cognition.Schizophrenia bulletin · 2026Article
- Depression, but not anxiety, is associated with epigenetic age accelerations among Asian older adults.Molecular psychiatry · 2026Article
- Neighborhood disadvantage and accelerated epigenetic aging in the early aftermath of trauma: The moderating role of individual psychological resources.Journal of psychiatric research · 2026Article
- Adverse life events and cognition in older adults: the role of gender and psychological resilience.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Resilience and Social Support as Predictors of Life Satisfaction in Healthy Older Adults: A Moderation Analysis.Actas espanolas de psiquiatria · 2026Article
- Dysglycemia-Based Chronic Disease and Lifestyle Medicine: Mechanistic Interpretation Using the Allostatic Load Model.American journal of lifestyle medicine · 2026Review
- The role of health behaviors in links between stress and epigenetic aging.Brain, behavior, & immunity - health · 2026Article
- Epigenetic Clocks, Resilience, and Multi-Omics Ageing: A Review and the EpiAge-R Conceptual Framework.International journal of molecular sciences · 2026Review
- Coping strategies as mediators of the relationship between fertility quality of life and psychological resilience among infertile patients: a cross-sectional mediation analysis.BMC women's health · 2026Article
- Review
- Integrative Aesthetics: Shaping the Emerging Frontier of Modern Aesthetic Medicine.Clinical, cosmetic and investigational dermatology · 2026Review
- Epigenetic clocks moderate the impact of marital status transitions on health in older adults.PloS one · 2026Article
- What we get wrong about stress in sports psychology: an opinion.Frontiers in psychology · 2026Article
- Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions.Frontiers in aging · 2026Review
- Epigenetic regulation of brain development, plasticity, and response to early-life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Allostatic load as a framework for understanding early-onset colorectal cancer: current biomarker evidence and future directions.Frontiers in oncology · 2026Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Our society is experiencing more stress than ever before, leading to both negative psychiatric and physical outcomes. Chronic stress is linked to negative long-term health consequences, raising the possibility that stress is related to accelerated aging. In this study, we examine whether resilience factors affect stress-associated biological age acceleration. Recently developed "epigenetic clocks" such as GrimAge have shown utility in predicting biological age and mortality. Here, we assessed the impact of cumulative stress, stress physiology, and resilience on accelerated aging in a community sample (N = 444). Cumulative stress was associated with accelerated GrimAge (P = 0.0388) and stress-related physiologic measures of adrenal sensitivity (Cortisol/ACTH ratio) and insulin resistance (HOMA). After controlling for demographic and behavioral factors, HOMA correlated with accelerated GrimAge (P = 0.0186). Remarkably, psychological resilience factors of emotion regulation and self-control moderated these relationships. Emotion regulation moderated the association between stress and aging (P = 8.82e-4) such that with worse emotion regulation, there was greater stress-related age acceleration, while stronger emotion regulation prevented any significant effect of stress on GrimAge. Self-control moderated the relationship between stress and insulin resistance (P = 0.00732), with high self-control blunting this relationship. In the final model, in those with poor emotion regulation, cumulative stress continued to predict additional GrimAge Acceleration even while accounting for demographic, physiologic, and behavioral covariates. These results demonstrate that cumulative stress is associated with epigenetic aging in a healthy population, and these associations are modified by biobehavioral resilience factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.