Evidence map›Paper›PMID 34839102›Full record

ArticleInternational journal of hygiene and environmental health2022

Proximity to endocrine-disrupting pesticides and risk of testicular germ cell tumors (TGCT) among adolescents: A population-based case-control study in California.

Scott J Swartz, Libby M Morimoto, Todd P Whitehead, Mindy C DeRouen, Xiaomei Ma, Rong Wang, Joseph L Wiemels, Katherine A McGlynn, Robert Gunier, Catherine Metayer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hygiene and environmental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Incidence of childhood cancer in Latin America and the Caribbean: coverage, patterns, and time trends.Revista panamericana de salud publica = Pan American journal of public health · 2024
    Article
  9. Article
  10. Endocrine-Disrupting Chemicals and Disease Endpoints.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Scott J SwartzJoint Medical Program, University of California, Berkeley/San Francisco, Berkeley, CA, USA; School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Libby M MorimotoDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.
Todd P WhiteheadDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.
Mindy C DeRouenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Xiaomei MaDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Rong WangDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Joseph L WiemelsCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Katherine A McGlynnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Robert GunierDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.
Catherine MetayerDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA. Electronic address: cmetayer@berkeley.edu.
University of California, Berkeley · USUniversity of California, San Francisco · USYale University · USBerkeley Public Health Division · USNational Cancer Institute · USUniversity of Southern California · US

Funding

Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
Perinatal hormonal biomarkers and risk of testicular germ cell tumorsR21CA185725 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2014 to 2015
$375k
Intramural NIH HHS Z99 CA999999NCI NIH HHS R21 CA185725
6 · The paper itself

Abstract

backgroundThe incidence of testicular germ cell tumors (TGCT) is increasing steadily in the United States, particularly among Latinos. TGCT is thought to be initiated in utero and exposure to endocrine-disrupting chemicals, suspected contributors to TGCT pathogenesis, during this critical developmental period may contribute to the rise.

objectivesTo assess the relationship between fetal exposure to agricultural endocrine-disrupting pesticides (EDPs) and TGCT risk among adolescents in a diverse population in California.

methodsWe conducted a registry-based case-control study of TGCT. Cases, diagnosed between 1997 and 2011, were 15-19 years of age (n = 381). Controls were matched on birth year and race/ethnicity (n = 762). Quantities (kilograms) of 33 pesticides applied within 3 km and 1 km radii of each individual's address before birth were estimated using the Pesticide Use Reporting database. Odds ratios (OR), 95% confidence intervals (CI), and population attributable risk (PAR) were calculated for each EDP (using log-2 transformed values). Risk models considered race/ethnicity, birth year, and neighborhood socioeconomic status.

resultsA doubling of nearby acephate applications (3 km and 1 km radii) and malathion applications (1 km radius) was associated with increased risks of TGCT among Latinos only (OR = 1.09; 95% CI:1.01-1.17; 1.30; 95% CI:1.08-1.57, and 1.19; 95% CI:1.01-1.39, respectively), whereas application of carbaryl within a 3 km radius increased TGCT risk in non-Latinos only (OR = 1.14, 95% CI:1.01-1.28). We estimate that acephate was associated with approximately 10% of the TGCT PAR, malathion with 3% and carbaryl with 1%.

conclusionsTGCT among adolescents in California was associated with prenatal residential proximity to acephate and malathion among Latinos, and with carbaryl among non-Latinos. These results suggest that the rise in TGCT risk among Latinos may be associated with exposure to these pesticides.

Indexed as

Neoplasms, Germ Cell and EmbryonalPesticidesAdolescentCaliforniaCase-Control StudiesFemaleHumansMalePregnancyRisk FactorsTesticular NeoplasmsUnited StatesPesticidesAdolescent and young adultsEndocrine disruptorsEpidemiologyPesticidesTesticular cancerTesticular dysgenesis syndrome

Identifiers

PMID34839102
PMCPMC12980807
OpenAlexW3217720674

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.