ArticleExperimental eye research2022
Melanopsin modulates refractive development and myopia.
Article in Experimental eye research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Associations between systemic melatonin and human myopia: A systematic review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Pooled it
- Prevention of myopia in a near-primate by supplemental indigo light suggests a hypothesis for the myopia boom.Cell reports. Medicine · 2026Article
- Beyond Screen Time: A Measurement Framework for Behavioral Exposures in Childhood Myopia.Life (Basel, Switzerland) · 2026Review
- Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus.Investigative ophthalmology & visual science · 2026Article
- Light intensity and light/dark cycles regulate refractive development and myopia in mice through circadian rhythm-related genes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Review
- The Effect of Optic Nerve Crush on Lens-Induced Myopia in Mice.Ophthalmology science · 2026Article
- Light and myopia: a focus on the expanding role of non-visual opsins.Eye and vision (London, England) · 2026Review
- The role of circadian rhythms in the pathogenesis of myopia.Frontiers in physiology · 2026Review
- Illuminating Risk: An Ecological Analysis of Artificial Light at Night and Childhood Myopia Using State-Level US Data.Risk management and healthcare policy · 2026Article
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
- The interplay between form deprivation and dopamine signaling in regulating the expression of circadian rhythm-related genes in the retina of mice.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- IMI-Interventions for Controlling Myopia Onset and Progression 2025.Investigative ophthalmology & visual science · 2025Review
- IMI-2025 Digest.Investigative ophthalmology & visual science · 2025Article
- Blue-Light Stimulation for Myopia Prevention: Only Retinal but Not Optic Disc Stimulation Modulates the Pattern ERG.Life (Basel, Switzerland) · 2025Article
- Nonlinear spatial integration allows the retina to detect the sign of defocus in natural scenes.Science advances · 2025Article
- Article
- Optical and Visual Diet in Myopia.Investigative ophthalmology & visual science · 2025Review
- Light-eye-body axis: exploring the network from retinal illumination to systemic regulation.Theranostics · 2025Review
- The neural signature of high myopia: structural and functional brain alterations and their cognitive-emotional associations.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Myopia, or nearsightedness, is the most common form of refractive abnormality and is characterized by excessive ocular elongation in relation to ocular power. Retinal neurotransmitter signaling, including dopamine, is implicated in myopic ocular growth, but the visual pathways that initiate and sustain myopia remain unclear. Melanopsin-expressing retinal ganglion cells (mRGCs), which detect light, are important for visual function, and have connections with retinal dopamine cells. Here, we investigated how mRGCs influence normal and myopic refractive development using two mutant mouse models: Opn4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.