Evidence map›Paper›PMID 34838664›Full record

ArticleNeurobiology of disease2022

Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents.

Aliza A Le, Julian Quintanilla, Mohammad Amani, Daniele Piomelli, Gary Lynch, Christine M Gall

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. The how and why for multiple forms of hippocampal LTP.Frontiers in synaptic neuroscience · 2026
    Review
  2. Article
  3. Adolescent exposure to Δ9-tetrahydrocannabinol impairs testicular function in young adult male mice.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  4. Microglia Support Both the Singular Form of LTP Expressed by the Lateral Perforant Path and Episodic Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. The effect of traumatic brain injury on learning and memory: A synaptic focus.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025
    Review
  6. Neural basis of adolescent THC-induced potentiation of opioid responses later in life.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  7. Article
  8. Metabotropic NMDAR Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Article
  10. Pre- versus Post-synaptic Forms of LTP in Two Branches of the Same Hippocampal Afferent.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  11. Article
  12. Sex differences in the context dependency of episodic memory.Frontiers in behavioral neuroscience · 2024
    Article
  13. Consequences of adolescent drug use.Translational psychiatry · 2023
    Review
  14. Review
  15. Postnatal GABAMolecular neurobiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aliza A LeDepartments of Anatomy & Neurobiology, University of California, Irvine, CA 92697, United States of America.
Julian QuintanillaDepartments of Anatomy & Neurobiology, University of California, Irvine, CA 92697, United States of America.
Mohammad AmaniDepartments of Anatomy & Neurobiology, University of California, Irvine, CA 92697, United States of America.
Daniele PiomelliDepartments of Anatomy & Neurobiology, University of California, Irvine, CA 92697, United States of America.
Gary LynchDepartments of Anatomy & Neurobiology, University of California, Irvine, CA 92697, United States of America; Departments of Psychiatry & Human Behavior, University of California, Irvine, CA 92868, United States of America. Electronic address: ga.s.lynch@gmail.com.
Christine M GallDepartments of Anatomy & Neurobiology, University of California, Irvine, CA 92697, United States of America; Departments of Neurobiology & Behavior, University of California, Irvine, CA 92697, United States of America. Electronic address: cmgall@uci.edu.
University of California, Irvine · US

Funding

Impact of Cannabinoid Across the Lifespan (ICAL)P50DA044118 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Stephen Vincent Mahler · 2018 to 2026
$18.2M
Training Program in Learning and MemoryT32MH119049 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE L MCNAUGHTON, Manuella Yassa · 2019 to 2026
$1.4M
NIDA NIH HHS P50 DA044118NIMH NIH HHS T32 MH119049
6 · The paper itself

Abstract

There is evidence that cannabis use during adolescence leads to memory and cognitive problems in young adulthood but little is known about effects of early life cannabis exposure on synaptic operations that are critical for encoding and organizing information. We report here that a 14-day course of daily Δ

Indexed as

DronabinolMemory, EpisodicAnimalsFemaleHippocampusLong-Term PotentiationMaleMiceNeuronal PlasticityRatsRodentiaSynaptic TransmissionDronabinolCA1CannabinoidEstrogenFrequency facilitationhippocampusLateral perforant pathLong-term potentiationSex differencesSpatial learningTHC

Identifiers

PMID34838664
PMCPMC10249649
OpenAlexW3216773333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.