Evidence map›Paper›PMID 34838540›Full record

ArticleKidney international2022

Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin.

Mark R Hanudel, Brian Czaya, Shirley Wong, Maxime Rappaport, Shweta Namjoshi, Kristine Chua, Grace Jung, Victoria Gabayan, Bo Qiao, Elizabeta Nemeth and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. ValpalfInternational journal of molecular sciences · 2024
    Article
  6. Observational
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Mark R HanudelDepartment of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA. Electronic address: mhanudel@mednet.ucla.edu.
Brian CzayaDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Shirley WongDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Maxime RappaportDepartment of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Shweta NamjoshiDepartment of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Kristine ChuaDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Grace JungDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Victoria GabayanDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Bo QiaoDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Elizabeta NemethDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Tomas GanzDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

Iron physiology and pathology in pregnancyR01HD096863 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEMETH, ELIZABETA · 2019 to 2023
$2.1M
NICHD NIH HHS R01 HD096863
6 · The paper itself

Abstract

Ferric citrate is approved as an iron replacement product in patients with non-dialysis chronic kidney disease and iron deficiency anemia. Ferric citrate-delivered iron is enterally absorbed, but the specific mechanisms involved have not been evaluated, including the possibilities of conventional, transcellular ferroportin-mediated absorption and/or citrate-mediated paracellular absorption. Here, we first demonstrate the efficacy of ferric citrate in high hepcidin models, including Tmprss6 knockout mice (characterized by iron-refractory iron deficiency anemia) with and without adenine diet-induced chronic kidney disease. Next, to assess whether or not enteral ferric citrate absorption is dependent on ferroportin, we evaluated the effects of ferric citrate in a tamoxifen-inducible, enterocyte-specific ferroportin knockout murine model (Villin-Cre-ER

Indexed as

Anemia, Iron-DeficiencyCation Transport ProteinsAnimalsFerric CompoundsFerroportinHepcidinsHumansIronMiceCation Transport Proteinsferric citrateFerric CompoundsFerroportinHepcidinsIronanemiachronic kidney diseaseferric citrateferroportinhepcidiniron

Identifiers

PMID34838540
PMCPMC8940695
OpenAlexW3217302499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.