Trial reportJournal of the American Pharmacists Association : JAPhA
Pharmacists and community health workers improve medication-related process outcomes among Cambodian Americans with depression and risk for diabetes.
Trial report in Journal of the American Pharmacists Association : JAPhA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Pharmacist input to depression screening and management in patients with diabetes: a systematic review.International journal of clinical pharmacy · 2026Pooled it
- The impact of interprofessional collaboration between pharmacists and community health workers on medication adherence: a systematic review.International journal for equity in health · 2025Pooled it
- Do health education initiatives assist socioeconomically disadvantaged populations? A systematic review and meta-analyses.BMC public health · 2023Pooled it
- Secondary analysis of a randomized trial testing community health educator interventions for diabetes prevention among refugees with depression: effects on nutrition, physical activity and sleep.The international journal of behavioral nutrition and physical activity · 2023Trial
- Community-based diabetes prevention randomized controlled trial in refugees with depression: effects on metabolic outcomes and depression.Scientific reports · 2023Trial
- Design of a randomized controlled trial using a community-academic partnership to improve medication adherence: MI-CARE study protocol and implementation.Contemporary clinical trials · 2026Article
- Community Health Workers' and Pharmacists' Perspectives of a CHW-Pharmacist Collaboration Model to Support Medication Adherence.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Interprofessional collaboration between pharmacists and community health workers: a scoping review.International journal for equity in health · 2025Article
- Bridging communities, prevention, and heart health: U.S. strategies for CHW cardiovascular training and integration.Frontiers in epidemiology · 2025Review
- The evolving role of pharmacists in depression care: a scoping review.International journal of clinical pharmacy · 2024Article
- Development and Validation of a Community-Based Prediction Model for Depression in Elderly Patients with Diabetes: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Community Health Workers Bridging the Gap: Connecting Medicaid Members with Providers, Managed Care, and Community-Based Organizations.Risk management and healthcare policy · 2024Article
- Risk factors for drug therapy problems among Cambodian Americans with complex needs: a cross-sectional, observational study.Health psychology and behavioral medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundCambodian Americans have high rates of cardiometabolic and psychiatric disorders and disadvantaged social determinants of health (SDOH). These factors can make it challenging to resolve drug therapy problems (DTPs) and improve medication-related outcomes. This manuscript reports planned analyses from a randomized controlled trial in which participants were randomized to one of 3 treatment arms: (1) community health worker (CHW)-delivered lifestyle intervention called Eat, Walk, sleep (EWS), (2) EWS plus pharmacist/CHW-delivered medication therapy management (EWS + MTM), or (3) social services (SS: control).
objectivesWe compared the 3 arms on changes in self-reported medication adherence, barriers, and beliefs. Within the EWS + MTM arm only, we assessed the impact of EWS + MTM on DTP resolution and examined predictors of DTP resolution.
methodsCambodian Americans at the age of 35-75 years at high risk of developing diabetes and meeting the criteria for likely depression (N = 188) were randomized (EWS, n = 67; EWS + MTM, n = 63; SS, n = 50; control). For all participants, self-reported surveys were collected at baseline, 12 months, and 15 months. DTPs were assessed on the same schedule but only for participants in the EWS + MTM.
resultsAll 3 groups reported a significant decrease in barriers to taking medications. Compared with the other arms, the EWS + MTM arm reported a decrease in forgetting to take medications at 15 months. In the EWS + MTM arm, mean DTPs per patient was 6.57 and 84% of DTPs were resolved. SDOH predictors of DTP resolution included years of education (odds ratio [OR] 0.94, P = 0.016), ability to write English (OR 0.73, P = 0.015), difficulty communicating with provider (OR 1.39, P < 0.001), private insurance (OR 1.99, P = 0.030), disability (OR 0.51, P = 0.008), and years living under Pol Pot (OR 0.66, P = 0.045). Medication barriers at baseline predicted DTP resolution (OR 0.79, P = 0.019) such that each additional barrier was associated with a 21% reduction (1-0.79) in the odds of having a resolution.
conclusionCHWs can reduce medications barriers and help pharmacists reduce DTPs in disadvantaged populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.