ArticleCancer imaging : the official publication of the International Cancer Imaging Society2021
Whole-body diffusion-weighted MRI of normal lymph nodes: prospective apparent diffusion coefficient histogram and nodal distribution analysis in a healthy cohort.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 18 citations in OpenAlex.
- Lymphoma classification with multi-parametric texture analysis of DWI and PET imaging in Hodgkin and non-Hodgkin lymphoma: a pilot study.Magma (New York, N.Y.) · 2026Article
- The role of multimodality imaging in selection, response assessment, and follow-up of patients receivingInsights into imaging · 2026Article
- The enigma of inverted lymph node architecture in pigs: insights into immune function and vaccination design.Frontiers in immunology · 2026Article
- A preliminary study on diffusion-weighted imaging with background suppression and maximum intensity projection for screening internal mammary lymph node metastasis of breast cancer.Acta radiologica open · 2025Article
- A Modular Mathematical Model of the Immune Response for Investigating the Pathogenesis of Infectious Diseases.Viruses · 2025Article
- Axillary Lymphadenopathy after COVID-19 Vaccination: Follow-up for Enlarged Lymph Nodes on MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Anatomy, Imaging, and Surgical Treatment of Thoracic Lymphadenopathies in Advanced Epithelial Ovarian Cancer.Cancers · 2024Review
- Review
- Article
- Future Directions in the Assessment of Axillary Lymph Nodes in Patients with Breast Cancer.Medicina (Kaunas, Lithuania) · 2023Review
- Role of Diffusion-Weighted Magnetic Resonance Imaging for Characterization of Mediastinal Lymphadenopathy.Diagnostics (Basel, Switzerland) · 2023Article
- Axillary Lymphadenopathy after Pfizer-BioNTech and Moderna COVID-19 Vaccination: MRI Evaluation.Radiology · 2023Article
- MRI visibility and displacement of elective lymph nodes during radiotherapy in head and neck cancer patients.Frontiers in radiology · 2022Article
- The Role of Whole-Body MRI in Patients with Lymphoma: A Narrative Review.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWhole body DWI (WB-DWI) enables the identification of lymph nodes for disease evaluation. However, quantitative data of benign lymph nodes across the body are lacking to allow meaningful comparison of diseased states. We evaluated apparent diffusion coefficient (ADC) histogram parameters of all visible lymph nodes in healthy volunteers on WB-DWI and compared differences in nodal ADC values between anatomical regions.
methodsWB-DWI was performed on a 1.5 T MR system in 20 healthy volunteers (7 female, 13 male, mean age 35 years). The b900 images were evaluated by two radiologists and all visible nodes from the neck to groin areas were segmented and individual nodal median ADC recorded. All segmented nodes in a patient were summated to generate the total nodal volume. Descriptors of the global ADC histogram, derived from individual node median ADCs, including mean, median, skewness and kurtosis were obtained for the global volume and each nodal region per patient. ADC values between nodal regions were compared using one-way ANOVA with Bonferroni post hoc tests and a p-value ≤0.05 was deemed statistically significant.
resultsOne thousand sixty-seven lymph nodes were analyzed. The global mean and median ADC of all lymph nodes were 1.12 ± 0.27 (10
conclusionsThe global mean and median ADC of all lymph nodes were 1.12 ± 0.27 (10
trial registrationRoyal Marsden Hospital committee for clinical research registration number 09/H0801/86, 19.10.2009.
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