Evidence map›Paper›PMID 34838113›Full record

ArticleDiabetology & metabolic syndrome2021

The interrelationship and accumulation of cardiometabolic risk factors amongst young adults in the United Arab Emirates: The UAE Healthy Future Study.

Fatima Mezhal, Abderrahim Oulhaj, Abdishakur Abdulle, Abdulla AlJunaibi, Abdulla Alnaeemi, Amar Ahmad, Andrea Leinberger-Jabari, Ayesha S Al Dhaheri, E Murat Tuzcu, Eiman AlZaabi and 22 more

Erratum issued Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Diabetology & metabolic syndrome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07742917 (Application of a Precision Lifestyle Medicine Clinical Program for a Sample of IFHAS Screening Cohort), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07742917 narecruitingnot on this mapstarted 2026, after this paper: background citation

Application of a Precision Lifestyle Medicine Clinical Program for a Sample of IFHAS Screening Cohort

TypeinterventionalSponsorInstitute for Healthier Living Abu DhabiRan2026 to 2027Enrolled150ConditionsObese Adults, BMI/Body Composition, Cardiometabolic Risk, Cardiovascular Disease RiskArmsPrecision Lifestyle Medicine Program, Standard IFHAS Care
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  12. Metabolic Syndrome in Fasting and Non-Fasting Participants: The UAE Healthy Future Study.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 13 institutions in 3 countries.

Fatima MezhalPublic Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE. Fam6@nyu.edu.
Abderrahim OulhajDepartment of Epidemiology and Public Health, College of Medicine and Health Sciences, Khalifa University of Sciences and Technology, Abu Dhabi, UAE.
Abdishakur AbdullePublic Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE.
Abdulla AlJunaibiDepartment of Pediatrics, Zayed Military Hospital, Abu Dhabi, UAE.
Abdulla AlnaeemiDepartment of Cardiology, Zayed Military Hospital, Abu Dhabi, UAE.
Amar AhmadPublic Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE.
Andrea Leinberger-JabariPublic Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE.
Ayesha S Al DhaheriDepartment of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE.
E Murat TuzcuHeart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
Eiman AlZaabiDepartment of Pathology, Sheikh Shakhbout Medical City, Abu Dhabi, UAE.
Fatma Al-MaskariInstitute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE.
Fatme AlanoutiCollege of Natural and Health Sciences, Zayed University, Abu Dhabi, UAE.
Fayza AlameriZayed Military Hospital, Abu Dhabi, UAE.
Habiba AlsafarCenter for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, UAE.
Hamad AlblooshiAbu Dhabi Blood Bank Services, SEHA, Al-Ain, Abu Dhabi, UAE.
Juma AlkaabiDepartment of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE.
Laila Abdel WarethPathology and Laboratory Medicine Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
Mai AljaberHealthpoint Hospital, Abu Dhabi, UAE.
Marina KazimAbu Dhabi Blood Bank Services, SEHA, Al-Ain, Abu Dhabi, UAE.
Micheal WeitzmanDepartment of Environmental Medicine, New York University of Medicine, New York, USA.
Mohammad Al-HouqaniDepartment of Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE.
Mohammad Hag AliDepartment of Health Science, Higher Colleges of Technology, Abu Dhabi, UAE.
Naima OumezianeAbu Dhabi Blood Bank Services, SEHA, Al-Ain, Abu Dhabi, UAE.
Omar El-ShahawyDepartment of Population Health, New York University School of Medicine, New York, USA.
Rami H Al-RifaiInstitute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE.
Scott SchermanDepartment of Population Health, New York University School of Medicine, New York, USA.
Syed M ShahInstitute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE.
Tom LoneyCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE.
Wael AlmahmeedHeart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
Youssef IdaghdourPublic Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE.
Luai A Ahmed *Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE.
Raghib Ali *Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE.
United Arab Emirates University · AEAbu Dhabi Health Services · AECleveland Clinic · USNew York University · USZayed Military Hospital · AEKhalifa University of Science and Technology · AEHealthpoint · AEHigher Colleges of Technology · AEMohammed Bin Rashid University of Medicine and Health Sciences · AENew York University Abu Dhabi · AESheikh Shakhbout Medical City · AEUniversity of Cambridge · GBZayed University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSimilar to other non-communicable diseases (NCDs), people who develop cardiovascular disease (CVD) typically have more than one risk factor. The clustering of cardiovascular risk factors begins in youth, early adulthood, and middle age. The presence of multiple risk factors simultaneously has been shown to increase the risk for atherosclerosis development in young and middle-aged adults and risk of CVD in middle age.

objectiveThis study aimed to address the interrelationship of CVD risk factors and their accumulation in a large sample of young adults in the United Arab Emirates (UAE).

methodsBaseline data was drawn from the UAE Healthy Future Study (UAEHFS), a volunteer-based multicenter study that recruits Emirati nationals. Data of participants aged 18 to 40 years was used for cross-sectional analysis. Demographic and health information was collected through self-reported questionnaires. Anthropometric data and blood pressure were measured, and blood samples were collected.

resultsA total of 5126 participants were included in the analysis. Comorbidity analyses showed that dyslipidemia and obesity co-existed with other cardiometabolic risk factors (CRFs) more than 70% and 50% of the time, respectively. Multivariate logistic regression analysis of the risk factors with age and gender showed that all risk factors were highly associated with each other. The strongest relationship was found with obesity; it was associated with four-fold increase in the odds of having central obesity [adjusted OR 4.70 (95% CI (4.04-5.46)], and almost three-fold increase odds of having abnormal glycemic status [AOR 2.98 (95% (CI 2.49-3.55))], hypertension (AOR 3.03 (95% CI (2.61-3.52))] and dyslipidemia [AOR 2.71 (95% CI (2.32-3.15)]. Forty percent of the population accumulated more than 2 risk factors, and the burden increased with age.

conclusionIn this young population, cardiometabolic risk factors are highly prevalent and are associated with each other, therefore creating a heavy burden of risk factors. This forecasts an increase in the burden of CVD in the UAE. The robust longitudinal design of the UAEHFS will enable researchers to understand how risk factors cluster before disease develops. This knowledge will offer a novel approach to design group-specific preventive measures for CVD development.

Indexed as

Cardiometabolic risk factorsCardiovascular diseaseCentral obesityDysglycemiaDyslipidemiaHypertensionMetabolic SyndromeObesity

Identifiers

PMID34838113
PMCPMC8627022
OpenAlexW3215637376

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.