SynthesisJournal of cardiothoracic surgery2021
The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis.
Synthesis in Journal of cardiothoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Diagnostic strategies for suspected acute aortic syndrome: systematic review, meta-analysis, decision-analytic modelling and value of information analysis.Health technology assessment (Winchester, England) · 2025Pooled it
- The Relationship Between Heart Rate and Mortality Risk in Patients With Acute Aortic Dissection: A Meta-Analysis.Reviews in cardiovascular medicine · 2025Pooled it
- Diagnostic accuracy of alternative biomarkers for acute aortic syndrome: a systematic review.Emergency medicine journal : EMJ · 2024Pooled it
- Article
- Type A Aortic Dissection: From Diagnosis to Cardiac Rehabilitation.Journal of clinical medicine · 2026Review
- Article
- Association of thrombocytopenia and D-dimer elevation with in-hospital mortality in acute aortic dissection.Annals of medicine · 2025Article
- Intraoperative Hemostatic Agents in Thoracic Aortic Surgery-A Scoping Review.Journal of clinical medicine · 2025Review
- Thoracic aortic aneurysm.Nature reviews. Disease primers · 2025Review
- A Narrative Review of Biomarkers and Imaging in the Diagnosis of Acute Aortic Syndrome.Diagnostics (Basel, Switzerland) · 2025Review
- How we manage a high D-dimer.Haematologica · 2024Review
- Risk factors for one-year mortality following discharge in patients with acute aortic dissection: development and validation of a predictive model in a cross-sectional study.BMC cardiovascular disorders · 2024Article
- Acute and chronic venous occlusion.The British journal of radiology · 2023Review
- [ROC curves: general characteristics and their usefulness in clinical practice].Revista medica del Instituto Mexicano del Seguro Social · 2023Article
- Cerebral Infarction as the Primary Presentation of Acute Aortic Dissection.Reviews in cardiovascular medicine · 2023Article
- Aortic dissection diagnosed with the aortic dissection detection risk score of 2 without D-dimer elevation.BMJ case reports · 2022Article
- Extensive aortic dissection (Stanford Type A) presenting with confusion in a patient: a case report.Radiology case reports · 2022Article
- The diagnostic and prognostic value of D-dimer in different types of aortic dissection.Journal of cardiothoracic surgery · 2022Article
- Changes of Serum D-Dimer, NT-proBNP, and Troponin I Levels in Patients with Acute Aortic Dissection and the Clinical Significance.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- A Retrospective Analysis of Serum D-Dimer Levels for the Exclusion of Acute Aortic Dissection.Open access emergency medicine : OAEM · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to evaluate the diagnostic value of D-dimer for acute aortic dissection (AAD) by the method of meta-analysis.
methodsPubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases from the establishment of the databases to December 2020 were systematically searched, and the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) system was used to evaluate the quality of the literature. STATA 15.0 software was applied to calculate the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (+LR), negative likelihood ratio (-LR) to draw summary receiver operating characteristics (SROC) curve and calculate the area under the curve (AUC). Meta-regression and subgroup analyses were used to explore the source of heterogeneity.
resultsA total of 16 clinical studies were enrolled in this study, including 1135 patients. The results of the meta-analysis showed that the pooled sensitivity was 0.96 (95% CI 0.91-0.98), the pooled specificity was 0.70 (95% CI 0.57-0.81), and the pooled DOR was 56.57 (95% CI 25.11-127.44), the pooled +LR was 3.25 (95% CI 2.18-4.85), the pooled -LR was 0.06 (95% CI 0.03-0.12), and the AUC was 0.94 (95% CI 0.91-0.95). Meta-regression and subgroup analysis results showed that publication year, sample size and cutoff value might be sources of heterogeneity. When the concentration of D-dimer was less than or equal to 500 ng/ml, the sensitivity significantly increased.
conclusionD-dimer has an excellent diagnostic value for AAD. It is a useful tool for detecting suspected AAD because of the excellent pooled sensitivity. D-dimer ≤ 500 ng/ml increases the potential to identify the suspected patients with AAD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.