Evidence map›Paper›PMID 34838048›Full record

ReviewJournal of nanobiotechnology2021

Application of nanotechnology in the diagnosis and treatment of bladder cancer.

Yadong Xu, Cheng Luo, Jieqiong Wang, Lingwu Chen, Junxing Chen, Tianfeng Chen, Qinsong Zeng

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
  2. Article
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  10. Review
  11. Exploring the molecular mechanism of Xiao Ji (Asian biomedicine : research, reviews and news · 2025
    Article
  12. Cancer stem cells and their role in metastasis.Central European journal of urology · 2025
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Nanomedicine in Bladder Cancer Therapy.International journal of molecular sciences · 2024
    Review
  20. Cancer centers of excellence for the multidisciplinary management of urologic cancers The intersection between education, research, and healthcare.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yadong Xu *Department of Urology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.ORCID http://orcid.org/0000-0002-9328-3454
Cheng Luo *Department of Urology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Jieqiong WangDepartment of Urology, Guangzhou First People's Hospital, Guangzhou, China.
Lingwu ChenDepartment of Urology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Junxing ChenDepartment of Urology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Tianfeng ChenDepartment of Chemistry, Jinan University, Guangzhou, 510632, China. tchentf@jnu.edu.cn.
Qinsong ZengDepartment of Urology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. zengqs3@mail.sysu.edu.cn.

Funding

First Affiliated Hospital of Sun Yat-sen University, horizontal topics about clinical research 2020SQGH10662National Natural Science Foundation of China 21877049Natural Science Foundation of Guangdong Province 2020B1515120043
6 · The paper itself

Abstract

Bladder cancer (BC) is a common malignancy in the genitourinary system and the current theranostic approaches are unsatisfactory. Sensitivity and specificity of current diagnosis methods are not ideal and high recurrence and progression rates after initial treatment indicate the urgent need for management improvements in clinic. Nanotechnology has been proposed as an effective method to improve theranosis efficiency for both non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). For example, gold nanoparticles (AuNPs) have been developed for simple, fast and sensitive urinary sample test for bladder cancer diagnosis. Nanoparticles targeting bladder cancers can facilitate to distinguish the normal and abnormal bladder tissues during cystoscopy and thus help with the complete removal of malignant lesions. Both intravenous and intravesical agents can be modified by nanotechnology for targeted delivery, high anti-tumor efficiency and excellent tolerability, exhibiting encouraging potential in bladder cancer treatment. Photosensitizers and biological agents can also be delivered by nanotechnology, intermediating phototherapy and targeted therapy. The management of bladder cancer remained almost unchanged for decades with unsatisfactory effect. However, it is likely to change with the fast-developed nanotechnology. Herein we summarized the current utility of nanotechnology in bladder cancer diagnosis and treatment, providing insights for the future designing and discovering novel nanoparticles for bladder cancer management.

Indexed as

NanoparticlesTheranostic NanomedicineUrinary Bladder NeoplasmsAnimalsHumansMiceUrinary BladderBladder cancerDiagnosisNanoparticlesNanotechnologyTherapy

Identifiers

PMID34838048
PMCPMC8626998

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.