Evidence map›Paper›PMID 34838009›Full record

ArticleBiomedical engineering online2021

Effect of limb rotation on radiographic alignment measurement in mal-aligned knees.

Xiaoshu Sun, Bin Yang, Shengzhao Xiao, Yichen Yan, Zifan Liu, Liang Yuan, Xiaohua Wang, Bin Sun, Jie Yao, Yubo Fan

Open access · goldAbstract read
In one paragraph

Article in Biomedical engineering online, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiaoshu Sun *Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China.
Bin Yang *Orthopedics Department, Peking University International Hospital, Life Park 1, Zhongguancun Life Science Park, Changping District, Beijing, People's Republic of China.
Shengzhao XiaoKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China.
Yichen YanKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China.
Zifan LiuKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China.
Liang YuanOrthopedics Department, Peking University International Hospital, Life Park 1, Zhongguancun Life Science Park, Changping District, Beijing, People's Republic of China.
Xiaohua WangOrthopedics Department, Peking University International Hospital, Life Park 1, Zhongguancun Life Science Park, Changping District, Beijing, People's Republic of China.
Bin SunOrthopedics Department, Peking University International Hospital, Life Park 1, Zhongguancun Life Science Park, Changping District, Beijing, People's Republic of China.
Jie YaoKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China. astromilk@163.com.ORCID http://orcid.org/0000-0003-0044-7307
Yubo FanKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China. yubofan@buaa.edu.cn.
Beihang University · CNPeking University · CN

Funding

Fundamental Research Funds for the Central Universities YWF-21-BJ-J-802National Natural Science Foundation of China 11302248National Natural Science Foundation of China 11421202National Natural Science Foundation of China NSFC. 11502014Peking University International Hospital Research Funds (CN) YN2016QN08Peking University International Hospital Research Funds (CN) YN2019ZD05Young Elite Scientist Sponsorship Program by CAST (CN) YESS20150048
6 · The paper itself

Abstract

purposeLong-leg-radiography (LLR) is commonly used for the measurement of lower limb alignment. However, limb rotations during radiography may interfere with the alignment measurement. This study examines the effect of limb rotation on the accuracy of measurements based on the mechanical and anatomical axes of the femur and tibia, with variations in knee flexion and coronal deformity.

methodsForty-five lower limbs of 30 patients were scanned with CT. Virtual LLRs simulating five rotational positions (neutral, ± 10[Formula: see text], and ± 20[Formula: see text] internal rotation) were generated from the CT images. Changes in the hip-knee-ankle angle (HKA) and the femorotibial angle (FTA) were measured on each image with respect to neutral values. These changes were related to knee flexion and coronal deformity under both weight- and non-weight-bearing conditions.

resultsThe measurement errors of the HKA and FTA derived from limb rotation were up to 4.84 ± 0.66[Formula: see text] and 7.35 ± 0.88[Formula: see text], respectively, and were correlated with knee flexion (p < 0.001) and severe coronal deformity (p < 0.001). Compared with the non-weight-bearing position, the coronal deformity measured in the weight-bearing condition was 2.62[Formula: see text] greater, the correlation coefficients between the coronal deformity and the deviation ranges of HKA and FTA were also greater.

conclusionsFlexion and severe coronal deformity have a significant influence on the measurement error of lower limb alignment. Errors can be amplified in the weight-bearing condition compared with the non-weight-bearing condition. When using HKA and FTA to represent the mechanical axis and the anatomical axis on LLR, limb rotation impacts the anatomic axis more than the mechanical axis in patients with severe deformities. Considering LLR as the gold standard image modality, attention should be paid to the measurement of knee alignment. Especially for the possible errors derived from weight-bearing long-leg radiographs of patients with severe knee deformities.

Indexed as

Osteoarthritis, KneeTibiaFemurHumansKnee JointLower ExtremityRange of Motion, ArticularAlignment measurementKnee coronal deformityKnee flexionLong-leg radiography

Identifiers

PMID34838009
PMCPMC8626971
OpenAlexW3198741129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.