Evidence map›Paper›PMID 34837991›Full record

ArticleBMC pregnancy and childbirth2021

Associations of COVID-19 lockdown with gestational length and preterm birth in China.

Moran Dong, Rui Qian, Jiaqi Wang, Jingjie Fan, Yufeng Ye, He Zhou, Brian Win, Eve Reid, Suijin Zheng, Yanyun Lv and 15 more

Open access · goldAbstract read
In one paragraph

Article in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  6. COVID-19 lockdowns affected birthing outcomes in a regional New South Wales Health District.The Australian & New Zealand journal of obstetrics & gynaecology · 2024
    Article
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 2 countries.

Moran Dong *Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, China.
Rui Qian *Statistical Information Center for Health and Family Planning Bureau of Foshan, Foshan, 528000, China.
Jiaqi Wang *School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510080, China.
Jingjie Fan *Department of Prevention and Health Care, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, 518028, China.
Yufeng Ye *Guangzhou Panyu Central Hospital, Guangzhou, 511400, China.
He ZhouSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510080, China.
Brian WinDivision of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Eve ReidDivision of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Suijin ZhengThe Affiliated Houjie Hospital, Guangdong Medical University, Dongguan, 523945, China.
Yanyun LvAffiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, 529030, China.
Yudong PuSongshan Lake Central Hospital of Dongguan City, Dongguan, 523808, China.
Hanwei ChenGuangzhou Panyu Central Hospital, Guangzhou, 511400, China.
Juan JinSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510080, China.
Qingmei LinFoshan Women and Children Hospital Affiliated to Southern Medical University, Foshan, 528000, China.
Xiaoyang LuoDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangzhou, 510000, China.
Guimin ChenSchool of Public Health, Southern Medical University, Guangzhou, 510515, China.
Yumeng ChenSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510080, China.
Zhongrong HeSchool of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.
Guanhao HeGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, China.
Shouzhen ChengNursing Department, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Jianxiong HuGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, China.
Jianpeng XiaoGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, China.
Wenjun MaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, No.601 West, Huangpu Road, Tianhe District, Guangzhou, 510632, China.
Tao LiuDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, No.601 West, Huangpu Road, Tianhe District, Guangzhou, 510632, China. gztt_2002@163.com.
Xiaozhong WenDivision of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Guangdong Pharmaceutical University · CNGuangdong Provincial Center for Disease Control and Prevention · CNUniversity at Buffalo, State University of New York · USJinan University · CNPanyu District Central Hospital · CNSouthern Medical University · CNSun Yat-sen University · CNFoshan Maternity and Child Health Care Hospital · CNGuangdong Medical College · CNGuangdong Provincial People's Hospital · CNShenzhen Maternity and Child Healthcare Hospital · CNSongshan Lake Materials Laboratory · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

Chinese Postdoctoral Science Foundation 2020T130020ZXFoshan Key Technology Project for COVID-19 2020001000376National Natural Science Foundation of China 42175181National Natural Science Foundation of China 81874276Natural Science Foundation of Guangdong Province 2019A1515011264Science and Technology Planning Project of Guangdong Province 2018B020207006Science and Technology Program of Guangzhou 202102080565
6 · The paper itself

Abstract

backgroundThe effects of COVID-19 lockdown measures on maternal and fetal health remain unclear. We examined the associations of COVID-19 lockdown with gestational length and preterm birth (PTB) in a Chinese population.

methodsWe obtained medical records of 595,396 singleton live infants born between 2015 and 2020 in 5 cities in Guangdong Province, South China. The exposed group (N = 101,900) included women who experienced the COVID-19 Level I lockdown (1/23-2/24/2020) during pregnancy, while the unexposed group (N = 493,496) included women who were pregnant during the same calendar months in 2015-2019. Cumulative exposure was calculated based on days exposed to different levels of emergency responses with different weighting. Generalized linear regression models were applied to estimate the associations of lockdown exposure with gestational length and risk of PTB (< 37 weeks).

resultsThe exposed group had a shorter mean gestational length than the unexposed group (38.66 vs 38.74 weeks: adjusted β = - 0.06 week [95%CI, - 0.07, - 0.05 week]). The exposed group also had a higher risk of PTB (5.7% vs 5.3%; adjusted OR = 1.08 [95%CI, 1.05, 1.11]). These associations seemed to be stronger when exposure occurred before or during the 23rd gestational week (GW) than during or after the 24th GW. Similarly, higher cumulative lockdown exposure was associated with a shorter gestational length and a higher risk of PTB.

conclusionsThe COVID-19 lockdown measures were associated with a slightly shorter gestational length and a moderately higher risk of PTB. Early and middle pregnancy periods may be a more susceptible exposure window.

Indexed as

AdultChinaCOVID-19FemaleGestational AgeHumansInfant, NewbornMaternal ExposurePregnancyPregnancy Complications, InfectiousPregnancy OutcomePremature BirthQuarantineYoung AdultChinaCOVID-19Gestational lengthLockdownPreterm

Identifiers

PMID34837991
PMCPMC8626761
OpenAlexW3173518913

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.