Evidence map›Paper›PMID 34837903›Full record

Observational studyAsian Pacific journal of cancer prevention : APJCP2021

Clinicopathological and Radiological Features with Long Term Follow Up of Metaplastic Carcinoma Breast in India.

Gopal Puri, Kush Raj Lohani, Sarada Khadka, Kamal Kataria, Piyush Ranjan, Smriti Hari, Sandeep Mathur, Anita Dhar, Anurag Srivastava

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Gopal PuriDepartment of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.ORCID 0000-0002-4328-1100
Kush Raj LohaniDepartment of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
Sarada KhadkaDepartment of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
Kamal KatariaDepartment of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
Piyush RanjanDepartment of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
Smriti HariDepartment of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.
Sandeep MathurDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Anita DharDepartment of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
Anurag SrivastavaDepartment of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMetaplastic breast carcinoma (MBC) is a heterogeneous group of invasive carcinomas with squamous and/or mesenchymal differentiation. Because of their rare occurrence, the information regarding the clinical behaviour of metaplastic carcinomas is limited. The purpose of our study was to delineate the clinicopathological and radiological features, treatment outcomes, prognostic factors, and survival of patients with MBC.

methodsAmbispective observational study with prospective recruitment was done from 1st January 2019 to 31st August 2020. Retrospective data included between 1st January 2009 and 31st December 2018. In the retrospective group surgical database of our department was searched and those with MBC diagnosis on post-operative histopathology recruited. In prospective group patients with MBC on core biopsy were followed and those operated were included. The patients followed up at our breast cancer clinic (BCC) and their demographic, clinical, pathological radiological and treatment details noted.

resultsForty patients formed the study population. The mean age of the patents was 42 years. Ipsilateral axillary lymph node metastasis was present in 22.5%. The pathological median tumor size was 5.4 (range 2.1 to 22 cm). The most common differentiation was cartilaginous (35%) followed by squamous (32.5%). The most common mammographic grading was BIRADS 4 (Breast Imaging Reporting and Data system). Magnetic resonance imaging was T2 hyperintense with peripheral rim enhancement and restriction on DWI. The median overall (OS) and disease-free survival (DFS) was 42 and 40 months, respectively. Fifteen patients (37.5%) had disease related mortality. A subgroup analysis revealed that, type of differentiation, histopathology and tumor size > 5cm affected both OS and DFS significantly.

conclusionMetaplastic breast cancer in our setup presents in young patients with aggressive large tumors at a higher stage and diverse histopathology and with comparable overall and disease-free survival. The histological subtype, tumor differentiation and tumor size are prognostic factors.

Indexed as

Magnetic Resonance ImagingMammographyAdultBiomarkers, TumorBreast NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHumansIndiaLymphatic MetastasisMiddle AgedNeoplasm GradingNeoplasm StagingPrognosisProspective StudiesBiomarkers, TumorMetaplastic Breast CarcinomaOverall and disease-free survivaltriple negative breast cancer

Identifiers

PMID34837903
PMCPMC9068179

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