Evidence map›Paper›PMID 34837895›Full record

SynthesisAsian Pacific journal of cancer prevention : APJCP2021

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma.

Seyedeh Fatemeh Parsaeian, Fatemeh Asadian, Mojgan Karimi-Zarchi, Sepideh Setayesh, Atiyeh Javaheri, Razieh Sadat Tabatabaie, Seyed Alireza Dastgheib, Hossein Golestanpour, Hossein Neamatzadeh

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Pooled it
  6. Article
  7. Article
  8. Article
  9. Polymorphisms of the interleukin-6 (Health science reports · 2023
    Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Seyedeh Fatemeh ParsaeianDepartment of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fatemeh AsadianDepartment of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran.
Mojgan Karimi-ZarchiEndometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
Sepideh SetayeshSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Atiyeh JavaheriDepartment of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Razieh Sadat TabatabaieDepartment of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyed Alireza DastgheibDepartment of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Hossein GolestanpourDepartment of Genetics, Marvdasht Branch, Azad University, Marvdasht, Iran.
Hossein NeamatzadehMother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn spite of substantial declines in both incidence and mortality rates in the past 50 years, cervical cancer remains one of the leading causes of cancer associated mortality among women globally. We performed this meta-analysis to explore the role of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629 and TLR9 rs352140 polymorphism with susceptibility to cervical carcinoma.

methodsThe search databases include PubMed, SciELO, MedRxiv, Web of Science, Scopus, Cochrane Library, China National Knowledge Infrastructure, and China Biology Medicine disc up to 30 June 2021. The language is limited to English and Chinese. The comparison between the polymorphisms and cervical cancer was assessed using pooled odds ratio (OR) and 95% confidence interval (CI). The data are statistically analyzed by Comprehensive Meta-Analysis (CMA) 2.0 software.

resultsA total of 59 studies including seven studies with 1,112 cases and 1,233 controls on XRCC3 rs861539, 14 studies with 2,694 cases and 3349 controls MTHFR rs1801133, four studies with 1,121 cases and 1,109 controls on IL-12B rs3212227, seven studies with 1,452 cases and 2,186 controls on IL-6 rs1800795, 20 studies with 4,781 cases and 4909 controls on TNF-α rs1800629, and seven studies with 1743 cases and 2292 controls on TLR9 rs352140 were included. There was a significant association between XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 polymorphisms and an increased risk of cervical carcinoma in overall population. However, the MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms were not associated.

conclusionThe pooled analysis showed that XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 were associated with cervical carcinoma susceptibility, but not MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms.

Indexed as

CarcinomaCase-Control StudiesDNA-Binding ProteinsFemaleGenetic Predisposition to DiseaseHumansInterleukin-12 Subunit p40Interleukin-6Methylenetetrahydrofolate Reductase (NADPH2)Odds RatioPolymorphism, GeneticRisk FactorsToll-Like Receptor 9Tumor Necrosis Factor-alphaUterine Cervical NeoplasmsDNA-Binding ProteinsIL12B protein, humanIL6 protein, humanInterleukin-12 Subunit p40Interleukin-6Methylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanTLR9 protein, humanToll-Like Receptor 9Tumor Necrosis Factor-alphaX-ray repair cross complementing protein 3Cervical cancercervical carcinomaGeneMeta-analysisPolymorphism

Identifiers

PMID34837895
PMCPMC9068191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.