Evidence map›Paper›PMID 34837887›Full record

ArticleAging2021

Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells.

Jiajia Zhang, Ping Wang, Yanli Cui

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jiajia ZhangDepartment of Laboratory, The Affiliated Hospital of Henan Polytechnic University, The Second People's Hospital of Jiaozuo, Jiaozuo 454001, Henan, P.R. China.
Ping WangDepartment of Hematology, The Affiliated Hospital of Henan Polytechnic University, The Second People's Hospital of Jiaozuo, Jiaozuo 454001, Henan, P.R. China.
Yanli CuiDepartment of Laboratory, The Affiliated Hospital of Henan Polytechnic University, The Second People's Hospital of Jiaozuo, Jiaozuo 454001, Henan, P.R. China.
Henan Polytechnic University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNA nuclear paraspeckle assembly transcript 1 (lncRNA NEAT1) is abnormally expressed in numerous tumors and functions as an oncogene, but the role of NEAT1 in laryngocarcinoma is largely unknown. Our study validated that NEAT1 expression was markedly upregulated in laryngocarcinoma tissues and cells. Downregulation of NEAT1 dramatically suppressed cell proliferation and invasion through inhibiting miR-524-5p expression. Additionally, NEAT1 overexpression promoted cell growth and metastasis, while overexpression of miR-524-5p could reverse the effect. NEAT1 increased the expression of histone deacetylase 1 gene (HDAC1) via sponging miR-524-5p. Mechanistically, overexpression of HDAC1 recovered the cancer-inhibiting effects of miR-524-5p mimic or NEAT1 silence by deacetylation of tensin homolog deleted on chromosome ten (PTEN) and inhibiting AKT signal pathway. Moreover,

Indexed as

Laryngeal NeoplasmsMicroRNAsPTEN PhosphohydrolaseRNA, Long NoncodingAcetylationAdultCell ProliferationFemaleHistone Deacetylase 1HumansMaleMiddle AgedNeoplasm InvasivenessHDAC1 protein, humanHistone Deacetylase 1MicroRNAsMIRN-524 microRNA, humanNEAT1 long non-coding RNA, humanPTEN PhosphohydrolasePTEN protein, humanRNA, Long Noncodinghistone deacetylationase 1laryngocarcinomalong noncoding RNA nuclear paraspeckle assembly transcript 1miR-524-5pphosphatase and tensin homolog /protein kinase B signaling pathway

Identifiers

PMID34837887
PMCPMC8660614
OpenAlexW3217012031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.